Results 51 to 60 of about 1,336,652 (309)

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calculating adult sex ratios from observed breeding sex ratios for wide‐ranging, intermittently breeding species

open access: yesEcosphere, 2021
A sex ratio is one of the most basic demographic estimates produced because it is easy to collect and provides deeper insight into population dynamics for the species under consideration.
J. E. Kahn   +4 more
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Patterns of silver eel (Anguilla anguilla L.) sex ratio in a catchment [PDF]

open access: yes, 2006
Changes in the numbers and size-class structure of European silver eels, Anguilla anguilla, in the River Fre´mur (France) were examined over a 9-year period after installation of downstream eel passes.
Guillouët, Jérôme   +9 more
core   +1 more source

Rainfall-driven sex-ratio genes in African buffalo suggested by correlations between Y-chromosomal haplotype frequencies and foetal sex ratio

open access: yesBMC Evolutionary Biology, 2010
Background The Y-chromosomal diversity in the African buffalo (Syncerus caffer) population of Kruger National Park (KNP) is characterized by rainfall-driven haplotype frequency shifts between year cohorts.
Greyling Barend J   +7 more
doaj   +1 more source

Altruism and sex ratio

open access: yesJournal of Theoretical Biology, 1982
Using precise genetic models, the evolution of the sex ratio in a population in which interactions between siblings exist but these interactions are not symmetrical with respect to the sexes has been studied. Some interesting differences between co-operative and aggressive models have emerged. © 1982.
openaire   +4 more sources

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Trends and seasonal variations in human secondary sex ratio in Southwest Nigeria: A 10-year survey

open access: yesAdvances in Human Biology, 2022
Introduction: Secondary sex ratio is the number of live male births per 100 female births. In humans, the primary sex ratio, which is the sex ratio at conception, is expected to be 1:1 in natural populations based on the law of independent assortment of ...
Samson Taiwo Fakorede   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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