Results 211 to 220 of about 1,617,182 (292)

Neonatal‐onset developmental and epileptic encephalopathy: High genetic yield and long‐term outcomes in a multicenter southern European cohort

open access: yesEpilepsia Open, EarlyView.
Abstract Objective To determine the genetic diagnostic yield, characterize the clinical and genetic landscape, and evaluate long‐term epilepsy, neurodevelopmental, and survival outcomes in a strictly defined cohort of neonatal‐onset developmental and epileptic encephalopathy (DEE).
Júlia Sala‐Coromina   +21 more
wiley   +1 more source

Development of a prognostic scoring system for systemic inflammatory response syndrome in donkeys

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Systemic inflammatory response syndrome (SIRS) is associated with increased mortality in horses with gastrointestinal (GI) disease. However, there are no data relating to naturally occurring SIRS in donkeys. Objectives To determine SIRS frequency in donkeys with GI disease. To develop a donkey‐specific prognostic SIRS score.
Marine A. Barnabé   +5 more
wiley   +1 more source

Altered gene expression in the liver and small intestine of horses with equine neuroaxonal dystrophy

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Equine neuroaxonal dystrophy/degenerative myeloencephalopathy (eNAD/EDM) is the second most common diagnosis of spinal ataxia in horses in the United States. The disease develops due to a combination of vitamin E deficiency and an unknown genetic risk factor(s), and there currently is no effective treatment.
Stephanie Ryan   +4 more
wiley   +1 more source

Autonomous Nanomedicine: Closing the Biological Validation Gap

open access: yesExploration, EarlyView.
Delivery of nanoparticles to tumors has not improved in over fifteen years, and biological testing remains slow and separate from formulation design. This review proposes adding a Biology step to the design cycle, using organ chips and patient‐derived organoids, and assesses the readiness of each required technology.
Yan Jun Lin, Izabella Komperda
wiley   +1 more source

Performing history, negotiating patriarchy: Actressing as gendered labor and the fragmentation of womanhood in Chinese historical costume drama

open access: yesFeminist Anthropology, EarlyView.
Abstract Gender inequality remains widespread in the film and television production industry, yet it is seldom examined in relation to backstage working environments. This article integrates on‐screen and off‐screen perspectives to investigate the working lives of Chinese actresses.
Yajie Li, Yuhao Ding
wiley   +1 more source

Oral Bacterial Extracellular Vesicles as Systemic Messengers: A Mouth–Gut–Systemic Axis Paradigm

open access: yesGut Medicine, EarlyView.
ABSTRACT Oral microbiome dysbiosis not only associated with localized periodontal disease but also with multiple systemic diseases, including cardiovascular disease, diabetes mellitus, Alzheimer's disease, rheumatoid arthritis, and cancer. However, the efficiency with which intact viable bacteria cross biological barriers to reach distant organs is ...
Yaping Huang   +5 more
wiley   +1 more source

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