Results 131 to 140 of about 5,820,468 (330)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

open access: yesAging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho   +4 more
wiley   +1 more source

The Sex Worker’s Work in the Streets and Bars of the City

open access: yesPsicologia, 2010
This article shows the differences and singularities of the sex workers’s (SW) situations in the central fair and in the bars of the city Campina Grande‑PB. It was used collective interviews techniques, general observation and work systematization.
Edil Ferreira da Silva   +2 more
doaj  

Socio-Cultural Risk? Reporting on a Qualitative Study with Female Street-Based Sex Workers [PDF]

open access: yes
Risk narratives are of increasing importance in contemporary social life in that they help in understanding and anticipating the shifts that characterise our late modern landscape.
Priscilla Dunk-West, Mary Leaker
core  

A Low Psoas Muscle Index Was Associated With a Poorer Overall Survival in Patients Who Underwent Percutaneous Nephrostomy

open access: yesAging and Cancer, EarlyView.
In patients with malignant ureteral obstruction undergoing percutaneous nephrostomy, sarcopenia defined by a low psoas muscle index was independently associated with poor overall survival on multivariate Cox regression analysis, suggesting that preoperative assessment of psoas muscle index may aid prognostic stratification in this population.
Kota Shimokihara   +3 more
wiley   +1 more source

Are sex assistants sex workers?

open access: yes, 2023
Le chapitre explore l'émergence et l'évolution de l'assistance sexuelle pour les personnes handicapées. L'auteur analyse comment cette pratique, bien que controversée, tente de se différencier de la prostitution en se positionnant comme une forme de thérapie sexuelle.
openaire   +1 more source

International Day to End Violence Against Sex Workers Dec. 17th. [PDF]

open access: yes
International Day to End Violence Against Sex ...
BC Coalition of Experimental Communities
core  

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

open access: yesAging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi   +3 more
wiley   +1 more source

Exploitasi Seks Terhadap Anak Perempuan yang Menjadi Korban Perdagangan Orang di Lokasi Prostitusi

open access: yesHumaniora, 2011
The special focus of this paper is the fenomen of girls who become sex workers. They are children under age of 18 year.  This paper will show that the girls who become sex workers were human trafficking victim for sex commercial purpose.
Yustinus Suhardi Ruman
doaj  

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi   +8 more
wiley   +1 more source

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