Results 71 to 80 of about 1,362,728 (245)

Child Sexual Abuse and Exploitation: Guest Editor’s Introduction

International Journal for Crime, Justice and Social Democracy, 2015
One of the most unnerving aspects of child sexual abuse is that it is constantly manifesting in unexpected ways. The current Royal Commission into Institutional Responses to Child Sexual Abuse has collected testimony of abuse in churches, schools, out-of-
Michael Salter
doaj   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Factors associated with access and utilization of sexual abuse emergency healthcare services among street children in Zomba, Malawi: a qualitative study

BMC Health Services Research
Background Sexual abuse among street children is a problem that renders a burden of sexually transmitted diseases, HIV infection, and early pregnancy. Literature shows that globally 95 million children experience sexual abuse with 1 in 5 girls and 1 in 7
Susan Mphatso Kacheyo, Lot Nyirenda
doaj   +1 more source

Traumatic sexuality after intrafamilial sexual abuse: a case report with compulsive sexual behaviour [PDF]

Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2011
Intrafamilial child sexual abuse is one of the most diffucult issue to be talked over and studied. All instances of abuse are not recognized or reported because of shame and guilt feelings, or hidden from other family members.
Songül Gündoğdu Kıran, Abdullah Atli, Yavuz Selvi, Pınar Güzel Özdemir   +3 more
doaj  

Exploring parental understanding of child sexual abuse and prevention as a measure for HIV prevention in Rwampara district.

PLoS ONE, 2022
BackgroundWorldwide, more than 95 million children are sexually abused each year with children in sub-Saharan Africa experiencing sexual assault at higher rates than those in more developed areas.
Aloysious Kamukama, Rachel Luwaga, Rodrick Tugume, Margaret Kanyemibwa, Betrace Birungi, Obed Ndyamuhika, Diana Ampire, Timothy Nduhukire, Deborah Lowell Shindell   +8 more
doaj   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Yes! Kissing Too… The Child Would Not Be Hurt in Any Way: Social Constructions of Child Sexual Abuse in the Ga Community in Ghana

Qualitative Sociology Review, 2019
The United Nations Convention on the Rights of the Child obligates nations to protect children from all forms of abuse including sexual. However, child sexual abuse is a complex phenomenon which is difficult to understand as a result of cultural reasons.
Ummu Markwei
doaj   +1 more source

Analysis of claims of child sexual abuse made with respect to Catholic Church institutions

, 2017
The Royal Commission has conducted a comprehensive survey of Catholic Church authorities in Australia to gather data about the extent of claims of child sexual abuse made against Catholic Church personnel.
Royal Commission into Institutional Responses to Child Sexual Abuse
core  

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source