Results 261 to 270 of about 7,089,812 (386)

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

“Sexual” behavior in parthenogenetic lizards ( Cnemidophorus )

, 1980
David Crews, Kevin T. Fitzgerald
openalex   +1 more source

Integration of Bioengineered Tools in Assisted Reproductive Technologies

Advanced Healthcare Materials, EarlyView.
A conceptual illustration depicting the collaboration between a medical professional (right) and a scientist (left). Their connection highlights the integration of scientific research and clinical practice. This representation underscores the role of emerging technologies in bridging fundamental research with applied reproductive healthcare.
Aslı Ak, Edith Coonen, Ron van Golde, Erik Vrij   +3 more
wiley   +1 more source

Hypothalamic Estrogen Receptor α Is Essential for Female Marmoset Sexual Behavior Without Protecting From Obesity. [PDF]

J Endocr Soc
Kraynak M, Willging MM, Uhlrich DJ, Shapiro RA, Flowers MT, Manning KA, John SD, Williams SM, Henjum LJ, Marrah RC, Yohnk HR, Berg CB, Brunner K, Colman RJ, Alexander AL, Abbott DH, Levine JE.   +16 more
europepmc   +1 more source

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

Advanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla, Prasanta K. Dash, Howard E. Gendelman   +6 more
wiley   +1 more source

Ancestral neural circuits potentiate the origin of a female sexual behavior in Drosophila. [PDF]

Nat Commun
Li M, Chen DS, Junker IP, Szorenyi FI, Chen GH, Berger AJ, Comeault AA, Matute DR, Ding Y.   +8 more
europepmc   +1 more source

Designing the Next Generation of Biomaterials through Nanoengineering

Advanced Materials, EarlyView.
Nanoengineering enables precise control over biomaterial interactions with living systems by tuning surface energy, defects, porosity, and crystallinity. This review highlights how these nanoscale design parameters drive advances in regenerative medicine, drug delivery, bioprinting, biosensing, and bioimaging, while outlining key translational ...
Ryan Davis Jr., Ishaan Duggal, Nicholas A. Peppas, Akhilesh K. Gaharwar   +3 more
wiley   +1 more source

Sexual trauma and compulsive sexual behavior in young men and women: A network analysis involving two samples. [PDF]

J Behav Addict
Scoglio AAJ, Chen YL, Huang KJ, Borgogna NC, Potenza MN, Blycker GR, Kraus SW.   +6 more
europepmc   +1 more source

High‐Entropy Materials for Water Splitting: An Atomic Nanoengineering Approach to Sustainable Hydrogen Production

Advanced Materials, EarlyView.
High‐entropy materials (HEMs), typically composed of five or more principal elements in near‐equimolar ratios, offer significant potential due to their unique properties. This review outlines the emergence and structural evolution of HEMs, followed by an in‐depth discussion of the elemental roles (active sites, promoters, or stabilizers) for water ...
Yufei Zhao, Jinhu Wu, Xianjun Cao, Dongfang Li, Peng Huang, Hong Gao, Qinfen Gu, Jinqiang Zhang, Guoxiu Wang, Hao Liu   +9 more
wiley   +1 more source

Editorial: Sexual behavior research: towards an understanding of CNS and spinal cord modulation of male sexual behavior and sexual dysfunctions. [PDF]

Front Neurosci
Gutiérrez-Ospina G, Bialy M.
europepmc   +1 more source