Results 61 to 70 of about 853,946 (301)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

THE DARK GLORY OF CRIMINALS NOTES ON THE ICONIC IMAGINATION OF THE MULTITUDES [PDF]

, 2013
This article explores the relationships between crime, collective responses to it, and the social production of so-called great criminals. It argues that crime, especially sexual and violent crime, produces significant imbalances in ...
Tonkonoff, Sergio
core   +2 more sources

Sexual Communication in the Drosophila Genus [PDF]

Insects, 2014
In insects, sexual behavior depends on chemical and non-chemical cues that might play an important role in sexual isolation. In this review, we present current knowledge about sexual behavior in the Drosophila genus. We describe courtship and signals involved in sexual communication, with a special focus on sex pheromones.
Gwénaëlle Bontonou, Claude Wicker-Thomas   +1 more
openaire   +3 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Conceptions of Consensual versus Non-Consensual Sexual Activity among Young People from Colombia

Behavioral Sciences
Conceptions or ideas that couples hold about sexual consent could be a key factor in their communication, mutual respect, and the prevention of sexual violence. The multifaceted nature of sexual consent makes it a complex concept.
Luis Enrique Prieto, Nieves Moyano
doaj   +1 more source

Quality of Marital Relationship and Sexual Interaction in Couples With Sexual Dysfunction: An Exploratory Study From India

Journal of Psychosexual Health, 2021
Background: Sexual dysfunction and marital intimacy and quality are found to have a reciprocal relationship. Examining this relationship in couples seeking help for sexual dysfunctions in the cultural context of India is worthwhile.
Manjula V., Manjula Munivenkatappa, Janardhana Navaneetham, Mariamma Philip   +3 more
doaj   +1 more source

The Influence of Marriage Communication Skills and Sexual Satisfaction on the Marriage Quality of Female Nurses at Mental Hospital [PDF]

, 2016
This research aims to investigate the influence of marriage communication skills and sexual satisfaction on the marriage quality of female nurses who work at a mental hospital and whose husbands also work.
Putra, M. G. (Muhammad), Sanjaya, E. L. (Ersa)   +1 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Communicating about Sexual Problems

Psycho-Oncologie, 2022
Sexual side effects of cancer treatment are common and, unfortunately, often not discussed with patients and their partner. This may be due to personal factors of the health care provider, fear of offending the patient or lack of knowledge, time constraints, and perception of the importance to the patient based on age and severity of the cancer ...
openaire   +1 more source