Results 41 to 50 of about 1,589 (239)

The interplay between molecular architecture, pharmacology, and suspected adverse drug reactions associated with nonsteroidal androgen antagonists in the United Kingdom

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to correlate potential links between the suspected adverse drug reaction (ADR) profile of licensed nonsteroidal androgen receptor antagonists (NSARA) with their unique chemical properties and known off‐target polypharmacology. Methods Physicochemical and polypharmacology data were curated from the Electronic Medicines Compendium ...
Simrit Dhillon, Albert A. Antolin, Alan M. Jones   +2 more
wiley   +1 more source

Acquired substance-dependent compulsivity but not general compulsivity predicts increased substance use

Discover Psychology
Background Substance misuse among college students is a growing area of concern. Approximately 2 in 5 college students suffer from binge drinking disorder, the consequences of which include sexual misconduct, low grade point average (GPA), injury, and ...
Mallory E. Jones, Paul Verhaeghen
doaj   +1 more source

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Biological Reviews, EarlyView.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater, Adam Dušek, Aleksandra Bartelik, Silvia Mandillo, Elisabetta Golini, Mara Rigamonti, Rasneer Sonia Bains, Hamish Forrest, Marion Rivalan, Melissa Long, Anna Kiryk, Lars Lewejohann, Nuno Henrique Franco   +12 more
wiley   +1 more source

Psychiatric comorbidity and compulsive/impulsive traits in compulsive sexual behavior

Comprehensive Psychiatry, 2003
In recent years there has been an increase in identifying and treating a clinical syndrome that has been given many different names, including compulsive sexual behavior (CSB). The purpose of this study was to determine the prevalence of psychiatric disorders in a sample of individuals with CSB, as evaluated by a structured psychiatric interview.
Nancy C, Raymond, Eli, Coleman, Michael H, Miner   +2 more
openaire   +2 more sources

CYP2C19 Genotype is Associated with Citalopram Treatment Outcomes in a Real‐World Setting

Clinical Pharmacology &Therapeutics, EarlyView.
CYP2C19 metabolizes various selective serotonin reuptake inhibitors (SSRIs) and genetic CYP2C19 variants are associated with SSRI tolerability and response. Yet, whether CYP2C19 variability also impacts citalopram response remained unclear. We here evaluated associations between CYP2C19 genotypes and citalopram prescription data of 11,079 patients from
Yoomi Park, Yitian Zhou, Volker M. Lauschke   +2 more
wiley   +1 more source

Genomic Insights Into Risperidone Treatment Outcomes in Children and Adolescents: Experience From a Psychiatric Hospital Serving Rural Youth

Clinical Pharmacology &Therapeutics, EarlyView.
Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited.
Jack W. Staples, Shayna R. Killam, Karen E. Brown, Rachel Dalton, Elizabeth Sather, Qiang Chen, Joshua Loveland, Corbin Schwanke, Abdallah F. Elias, Kristin L. Bigos, Erica L. Woodahl   +10 more
wiley   +1 more source

Adaptation and Pilot Evaluation of an Intervention Addressing the Sexual Health Needs of Gay Men Living with HIV Infection in Colombia

American Journal of Men's Health, 2021
Interventions addressing the sexual health need of HIV-positive men who have sex with men (MSM) in Latin America are scarce. We adapted and evaluated GPS, a group-based intervention led by peers, developed using the Information-Motivation-Behavioral (IMB)
Beatriz E. Alvarado MD, PhD, Jorge Luis Martinez-Cajas MD, Hector F Mueses MsC, Diego Correa Sanchez Psych, Barry D. Adam PhD, Trevor A. Hart PhD, C.Psych.   +5 more
doaj   +1 more source

Cannabidiol in Anorexia Nervosa: A Double‐Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder marked by an intense fear of gaining weight and persistent body dissatisfaction, both during periods of underweight and after weight restoration. The endocannabinoid system may offer therapeutic benefits, particularly in reducing anxiety.
Neha Sahota, David J. Grelotti, Tyler Nguyen, Walter H. Kaye, Skylar Swindle, Raymond Suhandynata, Spencer Seely, Megan E. Shott, Guido K. W. Frank   +8 more
wiley   +1 more source

Efficacy of the Intervention Against the Stigmatization of Men With Eating Disorders in Primary Healthcare (iSMEsH): Results From a Randomized Waitlist‐Controlled Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Eating disorders (EDs) in men are underdiagnosed and undertreated, partly due to stigma hindering help‐seeking. This randomized waitlist‐controlled study tested the efficacy of the iSMEsH online anti‐stigma intervention targeting German general practitioners (GPs) and medical students.
Martin S. Lehe, Georg Halbeisen, Sabine Steins‐Loeber, Georgios Paslakis   +3 more
wiley   +1 more source

Longitudinal influence of COVID-19-related stress on sexual compulsivity symptoms in Chinese undergraduates. [PDF]

BMC Psychiatry, 2021
Deng J, Li T, Wang J, Teng L.
europepmc   +2 more sources