Results 51 to 60 of about 830,064 (304)

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Reduction of female copulatory damage by resilin represents evidence for tolerance in sexual conflict [PDF]

, 2015
Intergenomic evolutionary conflicts increase biological diversity. In sexual conflict, female defence against males is generally assumed to be resistance, which, however, often leads to trait exaggeration but not diversification. Here, we address whether
Gorb, S. N., Michels, Jan, Reinhardt, K.
core   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Human Sexual Conflict from Molecules to Culture

Evolutionary Psychology, 2011
Coevolutionary arms races between males and females have equipped both sexes with mutually manipulative and defensive adaptations. These adaptations function to benefit individual reproductive interests at the cost of the reproductive interests of ...
Gregory Gorelik, Todd K. Shackelford
doaj   +1 more source

Conflict on the sex chromosomes: cause, effect, and complexity [PDF]

, 2014
Intralocus sexual conflict and intragenomic conflict both affect sex chromosome evolution and can in extreme cases even cause the complete turnover of sex chromosomes.
Hosken, DJ, Mank, JE, Wedell, N
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Health of girls-victims of military conflict

Zdorovʹe Rebenka, 2017
Background. To study peculiarities of physical and sexual development and menstrual function in girls from the military conflict area in the Eastern part of the country who receive treatment in the State Institution “Institute for Children and ...
V.A. Dynnik
doaj   +1 more source

Convergent recombination suppression suggests role of sexual selection in guppy sex chromosome formation. [PDF]

, 2017
Sex chromosomes evolve once recombination is halted between a homologous pair of chromosomes. The dominant model of sex chromosome evolution posits that recombination is suppressed between emerging X and Y chromosomes in order to resolve sexual conflict.
A Kortrschal, A Lindholm, A Loytynoja, A McKenna, A Rimmer, AE Houde, AE Houde, AE Wright, AE Wright, AE Wright, AE Wright, AP Lisachov, AR Quinlan, B Charlesworth, B Langmead, B Sandkam, B Vicoso, B Vicoso, B Vicoso, B Vicoso, BA Fraser, BJA Pollux, C Dufresnes, D Bachtrog, D Bachtrog, D Bachtrog, D Kim, DJ Kemp, DR Kelley, E Axelsson, E Eden, E Eden, E Paradis, G Lunter, H Li, H Li, H Skaletsky, H Skaletsky, I Nanda, J Haldane, J Hough, J Kitano, JA Endler, JA Endler, JA Endler, JA Endler, JE Mank, JE Mank, JE Mank, JE Mank, JE Mank, JP Masly, JRW Russell, K Reichwald, KP Arunkumar, M Lohse, M Pertea, M Stock, M White, M Winge, MD Robinson, MD Robinson, N Tripathi, P Flicek, PW Harrison, Q Zhou, R Bergero, R Chikhi, RA Fisher, RB Luo, RH Devlin, RP Meisel, RP Meisel, RW Meredith, S Anders, SF Altschul, SP Gordon, SP Gordon, T Jombart, T Kamiya, T Lenormand, W Traut, WR Rice, ZH Yang, ZY Liu   +84 more
core   +4 more sources

Sexual Conflict and Sperm Competition [PDF]

Cold Spring Harbor Perspectives in Biology, 2014
Traits that increase a male's fertilization success during sperm competition can be harmful to females and therefore represent a source of sexual conflict. In this review, we consider the variety of male adaptations to sperm competition (MASC) that may give rise to sexual conflict-including mate guarding, prolonged copulations, the transfer of large ...
Dominic A, Edward, Paula, Stockley, David J, Hosken   +2 more
openaire   +2 more sources