Results 61 to 70 of about 62,617 (288)

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Female sexual dysfunction: a focus on flibanserin

International Journal of Women's Health, 2017
Nicole M Lodise Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, NY, USA Abstract: Flibanserin is the first US Food and Drug Administration (FDA)-approved option for sexual dysfunction, specifically low sexual ...
Lodise NM
doaj  

Review: Testosterone therapy for reduced libido in women

Therapeutic Advances in Endocrinology and Metabolism, 2010
Modest benefit has been shown from transdermal testosterone therapy given to postmenopausal women with reduced sexual desire. An increased frequency of satisfying sexual encounters and intensity of sexual desire and response has been shown in medically ...
Rosemary Basson
doaj   +1 more source

Integration of Bioengineered Tools in Assisted Reproductive Technologies

Advanced Healthcare Materials, EarlyView.
A conceptual illustration depicting the collaboration between a medical professional (right) and a scientist (left). Their connection highlights the integration of scientific research and clinical practice. This representation underscores the role of emerging technologies in bridging fundamental research with applied reproductive healthcare.
Aslı Ak, Edith Coonen, Ron van Golde, Erik Vrij   +3 more
wiley   +1 more source

Designing the Next Generation of Biomaterials through Nanoengineering

Advanced Materials, EarlyView.
Nanoengineering enables precise control over biomaterial interactions with living systems by tuning surface energy, defects, porosity, and crystallinity. This review highlights how these nanoscale design parameters drive advances in regenerative medicine, drug delivery, bioprinting, biosensing, and bioimaging, while outlining key translational ...
Ryan Davis Jr., Ishaan Duggal, Nicholas A. Peppas, Akhilesh K. Gaharwar   +3 more
wiley   +1 more source

High‐Entropy Materials for Water Splitting: An Atomic Nanoengineering Approach to Sustainable Hydrogen Production

Advanced Materials, EarlyView.
High‐entropy materials (HEMs), typically composed of five or more principal elements in near‐equimolar ratios, offer significant potential due to their unique properties. This review outlines the emergence and structural evolution of HEMs, followed by an in‐depth discussion of the elemental roles (active sites, promoters, or stabilizers) for water ...
Yufei Zhao, Jinhu Wu, Xianjun Cao, Dongfang Li, Peng Huang, Hong Gao, Qinfen Gu, Jinqiang Zhang, Guoxiu Wang, Hao Liu   +9 more
wiley   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source

The role of sexual self-esteem, sexual desire, and sexual assertiveness in the female sexual function

Psicologia: Reflexão e Crítica
Background Sexual function plays a very important role in the sexual health of people, and the determination of their related factors reflects the importance of paying attention to sexual function in the cultural context.
Shokoufeh Roshan Chesli, Zahra Bostani Khalesi, Sara Shirzad Chenari   +2 more
doaj   +1 more source

Development and Validation of Machine Learning‐Based Marker for Early Detection and Prognosis Stratification of Nonalcoholic Fatty Liver Disease

Advanced Science, EarlyView.
This study constructs a stacked multimodal machine learning model for nonalcoholic fattly liver disease (NAFLD) by integrating genetic and clinical features, and synthesize an in‐silico quantitative marker (ISNLD) that enables personalized risk stratification for intrahepatic and extrahepatic outcomes of high‐risk individuals of NAFLD.
Lushan Xiao, Lin Zeng, Jiaren Wang, Chang Hong, Ziyong Zhang, Chengkai Wu, Hao Cui, Yan Li, Ruining Li, Shengxing Liang, Qijie Deng, Wenyuan Li, Xuejing Zou, Pengcheng Ma, Li Liu   +14 more
wiley   +1 more source

Halbert Index of Sexual Desire (HISD) Questionnaire Validation

روانشناسی بالینی و شخصیت, 2014
The main purpose of this study was evaluation of validity and reliability of HISD on a sample of Isfahan married men and women. 325 persons were selected among all married women and men visiting Isfahan cul-tural centers in two stages (75 persons in the ...
N. Yousefi, K. Farsani, A. Shakiba, S. Hemmati, J. Nabavi Hesar   +4 more
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