Results 71 to 80 of about 279,671 (260)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

A diferença como política de resistência e de ressignificação da subjetividade feminina em campos de saberes masculinos

open access: yesCiências Sociais Unisinos, 2017
This article analyzes narratives of women teachers inserted into the context of teaching Catholicism in a traditionally masculine space structured to be unintelligible to women.
Neiva Furlin, Marlene Tamanini
doaj  

The Postfeminist Masquerade and the Cynical Male Gaze: The Disavowal of Sexual Difference in Lars von Trier’s Breaking the Waves

open access: yesE-REA, 2014
This article is a commentary on the Lacanian appropriation of Breaking the Waves by Slavoj Zizek, Frances Restuccia and others who argue that the film’s saintly heroine, Bess, performs an authentic feminine act paradoxically in her very suicidal over ...
Tamas NAGYPAL
doaj   +1 more source

Sexual Difference Matters: Females with High Microsatellite Instability Show Increased Survival after Neoadjuvant Chemotherapy in Gastric Cancer. [PDF]

open access: yesCancers (Basel), 2021
Kohlruss M   +10 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Sexual Difference and the Uterus in Luis Mercado, Rodrigo de Castro, and Zacuto Lusitano

open access: yesActa Universitatis Lodziensis: Folia Litteraria Romanica
Many treatises on gynaecology of the sixteenth and seventeenth centuries describe the uterus as the cause of women’s diseases, according to a perspective inherited from the Hippocratic Corpus and Aretaeus. Simultaneously, however, and in a more positive
Cristina Pinheiro
doaj   +1 more source

Cross-Dressing as Ambisexual Style: Queer Twists in Virginia Woolf’s Orlando

open access: yesE-REA, 2019
This paper examines cross-dressing in Virginia Woolf’s Orlando. Reading the novel’s gender topsy-turviness in light of the carnivalesque 1910 Dreadnought Hoax, for which Woolf cross-dressed as an Abyssinian Prince, I explore the seductiveness of queer ...
Adèle CASSIGNEUL
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

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