Results 121 to 130 of about 39,264 (298)

Sexual dysfunction in heart failure patients

, 2014
Heart failure has a severe impact on different aspects of a patient’s life, including sexual function. Sexual problems are common in heart failure (HF) patients, both in men and women, and are not always adequately addressed and treated in the current ...
Mårtensson, Jan,, Jaarsma, Tiny,, Fridlund, Bengt,, Fridlund, Bengt, Mårtensson, Jan   +4 more
core   +1 more source

Journey into the Realm of Requests for Help Presented to Sexual Medicine Specialists: Introducing Male Sexual Distress

, 2007
Introduction. The recent availability of noninvasive pharmacological remedies for male sexual function triggered an exponential increase in the number of men requesting help in the sexuality area. Aim. The Italian Society of Andrology explored requests
Giorgio Piubello, A. Guidi, Furio Pirozzi Farina A. Isidori, E. A. Jannini, Bruno Giammusso, Vincenzo Gentile, M. Moro, M. Cingolani, Cinzia Caporali, F. Menchini Fabris, A. Sessa, A. Salsa, FERRACUTI, Stefano, Edoardo S. Pescatori   +13 more
core   +1 more source

The Impact of Cervical Cancer on the Sexuality of Muslim Female Patients with Husbands: A Qualitative Phenomenological Study

South East Asia Nursing Research
The treatment period for the cancer cervix and its treatment can also cause various change physical and physiological, which can cause various problems one of which is the disturbance of sex.
Hernandia Distinarista, Tutik Rahayu, Apriliani Yulianti Wuriningsih, Sri Wahyuni   +3 more
doaj   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

The Association of Higher Depressive Symptoms and Sexual Dysfunction in Male Haemodialysis Patients

, 2009
Background. The prevalence of sexual dysfunction among male haemodialysis patients is high. Sexual dysfunction is composed of both physiological and psychological factors. However, the role of pyschological depression is still obscure. Methods.
彭渝森;姜至剛;洪冠予;江守山;呂嘉陞;楊垂勳;吳寬墩;楊芝青;張啟仁;蔡敦仁;陳萬裕, PENG, YU-SEN;CHIANG, CHIH-KANG;HUNG, KUAN-YU;CHIANG, SHOU-SHAN;LU, CHIA-SHENG;YANG, CHWEI-SHIUN;WU, KWAN-DUN;YANG, CHIH-CHING;CHANG, CHEE-JEN;TSAI, TUN-JEN;CHEN, WAN-YU   +1 more
core   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Penile Prosthesis Infection: Myths and Realities

The World Journal of Men's Health, 2019
Penile prosthesis infection is the most significant complication following prosthesis implant surgery leading to postoperative morbidity, increased health care costs, and psychological stress for the patient.
Kevin J. Hebert, Tobias S. Kohler
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source