Results 211 to 220 of about 212,366 (345)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Linking Thyroid Function, Morphology, Autoimmunity, Body Mass Index, and Reproductive Aging to Women's Sexual Health: Evidence from a Population Study in Kaunas. [PDF]

J Clin Med
Daukšienė D, Klimaitė R, Kondrotienė A, Matukaitienė R, Čeponis J, Rimkutė A, Dudonytė L, Steponavičiūtė R, Lukšienė D, Lesauskaitė V, Veličkienė D, Verkauskienė R, Žilaitienė B.   +12 more
europepmc   +1 more source

Letter to the Editor. Re: single potential analysis of cavernous electrical activity in spinal cord injury patients. [PDF]

, 1994
Höppner, C., Jonas, Udo, Noack, T., Sauerwein, D., Stief, Christian Georg   +4 more
core   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source

Pelvic floor muscle therapy for sexual dysfunction in gynaecological cancer survivors. [PDF]

Cochrane Database Syst Rev
Vaidakis D, Bagiasta A, Sioulas V, Giannakidis D, Saitis A, Nikolakea M, Syristatidi AC, Papapanou M.   +7 more
europepmc   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Psychological and sexual impact of human papillomavirus screening in women in Cameroon: a prospective cohort study. [PDF]

BMC Womens Health
Sormani J, Moukam A, Wisniak A, Yakam V, Schmidt NC, Kenfack B, Petignat P.   +6 more
europepmc   +1 more source

Comparison of Pre‐ and Postoperative Gut Microbiota Diversity in Patients With Rectal Cancer Undergoing Stoma Creation and Closure

Annals of Gastroenterological Surgery, EarlyView.
We investigated the impact of temporary stoma creation and closure on gut microbiota diversity in rectal cancer patients. 16S rRNA sequencing revealed that microbial diversity significantly decreased postoperatively in the stoma group but remained stable in non‐stoma patients.
Yusuke Suzuki, Wataru Osumi, Kohei Taniguchi, Nahoko Kato‐Kogoe, Shoichi Sakaguchi, Shota Nakamura, Yoshiro Imai, Takashi Nakano, Takaaki Ueno, Sang‐Woong Lee   +9 more
wiley   +1 more source

Sexual Dysfunction in Female Rectal and Anal Cancer Survivors: Pathophysiology, Clinical Management, and Integration into Survivorship Care. [PDF]

Cancers (Basel)
Drittone D, Specchia M, Mazzotti E, Mazzuca F.   +3 more
europepmc   +1 more source

Time‐Dependent Recovery of Gastric Emptying After Gastrectomy: A 12‐Month Longitudinal Study Using a 13C‐Acetate Breath Test With a Semi‐Solid Meal

Annals of Gastroenterological Surgery, EarlyView.
This study examined time‐dependent changes in gastric emptying after gastrectomy for gastric cancer using a 13C‐acetate breath test with a semi‐solid meal in 95 patients, revealing that gastric emptying was initially delayed at 1 month but significantly accelerated by 12 months postoperatively.
Sachiko Kaida, Katsushi Takebayashi, Mika Kurihara, Reiko Otake, Haruki Mori, Hiromitsu Maehira, Toru Miyake, Shigeki Bamba, Masaji Tani   +8 more
wiley   +1 more source