Results 51 to 60 of about 39,264 (298)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Future sexual medicine physiological treatment targets

, 2010
INTRODUCTION: Sexual function in men and women incorporates physiologic processes and regulation of the central and peripheral nervous systems, the vascular system, and the endocrine system.
Kwangsung Park, BURNETT AL, Christ, George, Irwin Goldstein, Zhong C. Xin, PARK K, ARGIOLAS, ANTONIO, George Christ, CHRIST G, Antonio Argiolas, Goldstein, Irwin, Park, Kwangsung, Xin, Zhong C., GOLDSTEIN I, ANDERSSON KE, Karl-Erik Andersson, Andersson, Karl-Erik, Burnett, Arthur L., Arthur L. Burnett, XIN ZC   +19 more
core   +1 more source

Addressing Sexual Health in Oncology Patients

Acta Médica Portuguesa
N/a.
Margarida Alves, Diana Durães, Inês Fonseca   +2 more
doaj   +1 more source

Oral Testofen, L-Citrulline, Resveratrol, and Caffeine Supplement Drink Improves Sexual Function in Men with Phosphodiesterase 5 Inhibitors: Randomized, Double-Blind, Placebo-Controlled Crossover Pilot Study

The World Journal of Men's Health, 2021
Purpose: Sexuality is very important for men’s health. Currently, phosphodiesterase type 5 inhibitors (PDE5i) remain the firstline therapy for erectile dysfunction, and no other oral drugs or drinks are approved and used clinically to treat male libido
Masato Shirai, Yuto Miyoshi, Taiki Ogasa, Miho Miyoshi, Keisuke Ishikawa, Ippei Hiramatsu, Yuka Uesaka, Taiji Nozaki, Taro Koyama, Akira Tsujimura   +9 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Prescripción de Sildenafil en el policlínico docente "Manuel Fajardo Rivero"

Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2015
Fundamento: la sexualidad es ampliamente aceptada como una parte importante e integral del bienestar físico y emocional, un marcador del estado de salud y la calidad de vida del paciente.
Sarah María Regueira Betancourt, Manuel de Jesús Díaz Pérez, Julio Guillermo García Reyes, María Fernanda Ríos Cunalata   +3 more
doaj  

Sexual and gonadal dysfunction in chronic kidney disease: Pathophysiology

Indian Journal of Endocrinology and Metabolism, 2012
Sexual and gonadal dysfunction/infertility are quite common in patients with chronic kidney disease. Forty percent of male and 55% of female dialysis patients do not achieve orgasm. The pathophysiology of gonadal dysfunction is multifactorial.
Manish Rathi, Raja Ramachandran
doaj   +1 more source

Efficacy and Safety of Maca (Lepidium meyenii ) in Patients with Symptoms of Late-Onset Hypogonadism: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

The World Journal of Men's Health, 2023
Purpose: To evaluated the efficacy and safety of gelatinized Maca (Lepidium meyenii) for eugonadal patients with late onset hypogonadism symptoms (LOH).
Dongho Shin, Seung Hwan Jeon, Junjie Piao, Hyo Jung Park, Wen Jie Tian, Du Geon Moon, Sun Tae Ahn, Kyung-Hwa Jeon, Guan Qun Zhu, Ilbum Park, Hyun-Je Park, Woong Jin Bae, Hyuk Jin Cho, Sung-Hoo Hong, Sae Woong Kim   +14 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source