Results 81 to 90 of about 95,845 (291)

MCT1‐mediated Lactate Shuttle to Mitochondria Governs Macrophage Polarization and Modulates Glucose Homeostasis by Affecting β Cells

Advanced Science, EarlyView.
This study demonstrates that the transport of lactate to the mitochondria is of critical importance in determining the functions of macrophages by altering mitochondrial respiration. In macrophages, this lactate transport mechanism regulates glucose homeostasis by influencing the functions of insulin‐secreting cells in the pancreatic islets.
Lingling Chen, Yijun Lin, Xinyu Zhu, Shixuan Zhuo, Zixuan Li, Cheng Guo, Xiaoyi Ye, Jinzhu Chen, Shuying Wang, Yan Chen   +9 more
wiley   +1 more source

Asexuality: Classification and characterization [PDF]

, 2007
This is a post-print version of the article. The official published version can be obtaineed at the link below.The term “asexual” has been defined in many different ways and asexuality has received very little research attention.
A. Agmo, A. Bechara, A. F. Bogaert, A. Johnson, A. Riley, American Psychiatric Association, American Psychiatric Association, B. M. Alexander, B. N. Cuthbert, B. S. Mustanski, C. A. Hedricks, C. M. Steele, Cynthia A. Graham, D. A. Damassa, D. A. Strong, D. Bindra, D. Binson, D. J. Carlat, D. M. Green, E. Carmen, E. Cole, E. D. Rothblum, E. F. Hoon, E. F. Hoon, E. J. H. Meuleman, E. Janssen, Editors of the American Heritage Dictionaries, F. Montorsi, I. Spector, J. A. Gray, J. A. Vroege, J. Bancroft, J. Bancroft, J. D. Weinrich, J. G. Beck, J. H. Gray, J. M. Irvine, J. Rubin, J. S. Hyde, J. S. Hyde, K. A. Neuendorf, K. J. Zucker, L. Canin, L. F. O’Sullivan, L. M. Carpenter, L. M. Diamond, L. Schover, L. Zevy, M. Brezsnyak, M. Burisch, M. H. Birnbaum, M. S. Milligan, M. W. Ross, N. Haslam, Nicole Prause, P. S. Nurius, R. Basson, R. Green, R. L. Sell, R. R. Alteneder, R. Whalen, S. A. Brown, S. Deacon, T. D. Giargiari, V. E. Stone, W. Everaerd, W. Portillo, Y. M. Binik   +67 more
core   +1 more source

Nicotine Reprograms Aging‐Related Metabolism and Protects Against Motor Decline in Mice

Advanced Science, EarlyView.
Long‐term oral nicotine intake protects against age‐related motor decline in mice without eliciting systemic toxicity. Integrated multi‐organ metabolomic profiling and longitudinal gut microbiota analyses reveal that nicotine induces coordinated remodeling of glycolipid and sphingolipid metabolism, enhances NAD⁺ bioavailability, and suppresses ceramide
Shuhui Jia, Xiaoyuan Jing, Ruoxi Wang, Mengke Su, Pei Wang, Yingxin Feng, Xiaohu Ren, Longfang Tu, Ping Wei, Zhen Lu, Yicong Jia, Feng Hong, Zhizhun Mo, Jiemeng Zou, Kang Huang, Caiyun Yan, Qianhui Zou, Liang Wang, Guoping Zhong, Zhi Zeng, Qiuliyang Yu, Wen Su, Xifei Yang, Fan Pan, Jianzhi Wang, Liping Wang, Lijun Kang, Paul J. Kenny, Zuxin Chen, Xin‐an Liu   +29 more
wiley   +1 more source

Assessment of Sexual Health Knowledge, Attitudes, Practices and Dysfunction in Women Attending Obstetrics and Gynaecology OPD

Journal of Psychosexual Health
Background: Despite the fact that there have been significant advances in the prevention and treatment of sexual dysfunction in India, the majority of these have focused on male sexual dysfunction disorders and there is still a paucity of literature that
Bhumika Mishra, Sujatha MS, T S S Rao
doaj   +1 more source

Sexual Self-Efficacy and its Predictor Factors in Women with Multiple Sclerosis

مجله دانشکده پزشکی اصفهان, 2019
Background: Sexual problems are prevalent in women with multiple sclerosis (MS), and sexual self-efficacy as an effective variable plays an important role in sexual health and sexual quality of life of these women.
Vida Ghasemi, Masoumeh Simbar, Giti Ozgoli, Seyed Massood Nabavi, Hamid Alavi-Majd, Maryam Sadat Mirshafaei   +5 more
doaj   +1 more source

Immunolocalization of steroidogenic enzymes in the vaginal mucous of Galea spixii during the estrous cycle. [PDF]

, 2017
BackgroundThe synthesis of sex steroids is controlled by several enzymes such as17α-hydroxylase cytochrome P450 (P450c17) catalyzing androgen synthesis and aromatase cytochrome P450 (P450arom) catalyzing estrogen synthesis, both of which must complex ...
Assis Neto, Antônio Chaves de, Conley, Alan James, de Oliveira, Moacir Franco, Dos Santos, Amilton Cesar, Oliveira, Gleidson Benevides, Viana, Diego Carvalho   +5 more
core   +1 more source

Cuproptosis Signature Would Reveal the Acute‐Remitting Pattern in Patients with Neuromyelitis Optica Spectrum Disorder

Advanced Science, EarlyView.
Neuromyelitis optica spectrum disorder (NMOSD) has distinct acute‐remitting courses but lacks biomarkers for predicting relapse. Recent studies found cuproptosis‐related genes affect its course, and a model built accordingly can predict relapse to aid intervention.
Peidong Liu, Ruoyu Li, Xinlin Wang, Hui Li, Huiru Hu, Ang Shen, Wenping Zhu, Jiali Pan, Yanmeng Xing, Weiming Xia, Henan Jiao, Di Chen, Lixin Wu, Li Liu, Ju Liu, Bin Yu, Xianzhi Liu, Hongbo Liu   +17 more
wiley   +1 more source

Diabetes and sexual dysfunction: current perspectives

Diabetes, Metabolic Syndrome and Obesity, 2014
Maria Ida Maiorino,1 Giuseppe Bellastella,1 Katherine Esposito2 1Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Second University of Naples, Naples, Italy; 2Department of Clinical and Experimental Medicine, Second ...
Maiorino MI, Bellastella G, Esposito K
doaj  

RELATIONSHIP BETWEEN SEXUAL DYSFUNCTION AND SEXUAL SELF-CONCEPT IN PATIENTS WITH DIABETES MELLITUS: A SCOPING REVIEW

Nurse and Health
Background: An often-occurring complication of diabetes mellitus is sexual dysfunction, often linked to poor blood sugar control. Despite its significant impact on patients' lives, issues related to sexual desire, education, and timely detection and ...
Tiara Amalia Mentari, Haryanto
doaj   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source