Results 121 to 130 of about 1,777,079 (364)
Advanced Science, EarlyView.This study integrates scRNA‐seq, multiplex immunofluorescence, and clinical data to identify HLA‐DR⁺tumor cells uniquely enriched in Hepatocellular carcinoma (HCC) with hepatitis B virus (HBV). These cells express MHC II, associate with PD‐L1, recruit and exhaust CD8⁺T cells, predict poor survival, and serve as potential biomarkers for immunotherapy ...
Jun‐Qing Chang +17 more
wiley +1 more source
A Replication Study: Machine Learning Models Are Capable of Predicting Sexual Orientation From Facial Images [PDF]
arXiv, 2019 Recent research used machine learning methods to predict a person's sexual orientation from their photograph (Wang and Kosinski, 2017). To verify this result, two of these models are replicated, one based on a deep neural network (DNN) and one on facial morphology (FM).
arxiv
Letter: Management of sexual dysfunction. [PDF]
, 1976 Matt Swan, Llynwen Wilson
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SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
Advanced Science, EarlyView.During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong +9 more
wiley +1 more source
Vascular Health and Risk Management, 2023 Inmaculada Xu Lou,1,2,* Jiayue Chen,2,3,* Kamran Ali,4,* Qilan Chen2 1Department of Cardiology, International Education College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310053, People’s Republic of China; 2Department of ...
Lou IX, Chen J, Ali K, Chen Q
doaj
Advanced Science, EarlyView.Biosynthesis rates of 13 FFAs are quantitatively calculated in 15 tissues from glucose and an analytical framework to quantitatively calculate inter‐tissue communications of fatty acids between the liver and other tissues is developed. Moreover, the approach is extended to aging condition and a system‐wide decline of fatty acid synthesis in peripheral ...
Beizi Xing +4 more
wiley +1 more source
Current Trends and Future Directions for Sexual Health Conversational Agents (CAs) for Youth: A Scoping Review [PDF]
arXivConversational Agents (CAs, chatbots) are systems with the ability to interact with users using natural human dialogue. While much of the research on CAs for sexual health has focused on adult populations, the insights from such research may not apply to CAs for youth.
arxiv
SSRIs to treat sexual dysfunction [PDF]
, 1994 Siobhan MacHale, A. L. Phanjoo
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Advanced Science, EarlyView.Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie +9 more
wiley +1 more source