Results 161 to 170 of about 8,108 (263)

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

Disrupted Brain Structure and Function in Alzheimer's Disease Patients With Behavioral and Psychological Symptoms

iNew Medicine, EarlyView.
ABSTRACT Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in Alzheimer's disease (AD), but the underlying mechanisms are unclear. This study aims to elucidate the neuropathological mechanisms underlying BPSD by investigating gray matter volume (GMV) and brain connectivity in AD patients with and without BPSD.
Xuerui Pang, Linbo Xie, Mengdan Chen, Yi Ji, Yibing Yan, Shanshan Zhou, Panpan Hu, Xingqi Wu, Kai Wang   +8 more
wiley   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source

Adverse Childhood Experiences and Substance Use: The Mediating Role of Executive Function Deficits

Journal of Adolescence, EarlyView.
ABSTRACT Introduction While adverse childhood experiences (ACEs) are robust risk factors for adolescent substance use, the prospective neurocognitive pathways linking both cumulative and specific adversities to substance use remain understudied. This study tested a vulnerability model by examining whether executive function (EF) deficits mediate the ...
Mahsa P. Yousefkhani, Xiafei Wang, Sara A. Vasilenko   +2 more
wiley   +1 more source

Predicting Major Depression Among Diverse Online Gamers: The Role of Internet Addiction and Spirituality

Journal of Addictions &Offender Counseling, EarlyView.
ABSTRACT This study analyzed whether religious or spiritual affiliation and therapy enrollment protect against symptoms meeting Major Depressive Disorder criteria beyond demographic, Internet addiction, and described therapy enrollment. Findings illustrated one risk factor and one protective factor associated with experiencing symptoms that meet Major ...
Lindsay A. Lundeen, John R. McCall
wiley   +1 more source

Why Fun Aunties Matter: A Modest Account

Journal of Applied Philosophy, EarlyView.
ABSTRACT In this article, I offer a child‐centred account of the value of company‐keeping relationships between children and adults. These are relationships enjoyed by a child and an adult who is neither a mere acquaintance nor integrally involved in that child's care or upbringing.
Lesley Jamieson
wiley   +1 more source

Mindfulness and clinical hypnotherapy in sexual desire disorders: mechanisms, psychophysiological pathways, and integrative therapeutic sequencing. [PDF]

Front Psychiatry
Stompe T, Ritter N, Kostenwein W.
europepmc   +1 more source

Are Online Social Experiences Associated With General Interpersonal Problems? A Circumplex Assessment

Journal of Clinical Psychology, EarlyView.
ABSTRACT Objective Social media use can promote social connection but also often includes negative experiences, raising questions about its associations with broader interpersonal functioning. Methods This preregistered study used the interpersonal circumplex (IPC) to examine associations of self‐reported online social support and negativity, and ...
Timothy W. Smith, Giovanni Marquez, Dakota A. Dolister, Bert N. Uchino, Kevin D. Jordan   +4 more
wiley   +1 more source

Lifestyle and Selected Issues Related to Sexual Health: The Importance of Specialist Care in Balneology, Dietetics, and Physiotherapy. [PDF]

J Clin Med
Puszcz A, Kozłowska P, Wójcik J, Morawska A, Wójcik M, Plagens-Rotman K, Englert-Golon M, Mroczyk J, Mizgier M, Jakubek E, Pisarska-Krawczyk M, Sajdak S, Madziar K, Kędzia W, Jarząbek-Bielecka G.   +14 more
europepmc   +1 more source