Results 201 to 210 of about 16,459 (257)
Advanced Science, EarlyView.An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao +18 more
wiley +1 more source
Advanced Science, EarlyView.This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang +16 more
wiley +1 more source
Advanced Science, EarlyView.Inflammatory bowel disease (IBD) pathogenesis remains unclear. This study reveals that thymus‐originated IL‐7R‐enriched extracellular vesicles exacerbate colitis by promoting neutrophil extracellular traps via a thymus‐gut axis, uncovering an inter‐organ communication mechanism in inflammatory bowel disease pathogenesis.
Yao Liao +21 more
wiley +1 more source
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Sexual Dysfunction and Clomipramine
The Canadian Journal of Psychiatry, 1982Three cases of orgasmic inhibition by clomipramine are reported, one in a male and two infernales. All were depressed patients with obsessive-compulsive features. Orgasmic dysfunction manifested shortly after beginning clomipramine therapy despite a return of libido as the depression lifted.
K C, Quirk, T R, Einarson
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Sexual Anxiety in Sexual Dysfunction
British Journal of Psychiatry, 1989Sexual anxiety was examined in 98 patients presenting with sexual dysfunction and 68 of their partners at a psychosexual clinic using the SOMA questionnaire. All patients had raised values for heterosexual anxiety. Female partners had raised values while male partners did not.
D G, Patterson, E C, O'Gorman
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Fluoxetine and Sexual Dysfunction
JAMA: The Journal of the American Medical Association, 1995To the Editor. —In his response to a question from Dr Drucker about fluoxetine (Prozac) and sexual dysfunction, Dr Hollander 1 states that sexual dysfunction with fluoxetine occurs in up to 1.9% of patients. Even though the Physicians' Desk Reference 2 still carries this figure, this is no longer believed to reflect the true incidence of sexual ...
H S, Hopkins, A J, Gelenberg
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Dysfunctional sexual beliefs as vulnerability factors for sexual dysfunction
Journal of Sex Research, 2006The differences on sexual beliefs presented by men and women with sexual dysfunction and their sexually functional counterparts were investigated. A total of 488 participants (160 females and 232 males without sexual problems and 47 females and 49 males with a DSM-IV diagnosis of sexual dysfunction) answered the Sexual Dysfunctional Beliefs ...
Pedro Nobre, José Pinto-Gouveia
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Sexual Dysfunction in Schizophrenia
Focus, 2007Sexual dysfunctions have been described as being common in schizophrenia patients. The pathophysiology behind their development remains unclear. They can be secondary to the disease itself or an adverse event of antipsychotic medication. Therapeutic interventions are also not well studied.Earlier work has suggested that second-generation antipsychotics
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Sexual Dysfunction in Epilepsy
Epilepsia, 1991Summary: Sexual dysfunction may arise more frequently in men and women with epilepsy than with other chronic illnesses, manifesting primarily as diminished sexual desire and potency. Studies using retrospective self‐report of sexual attitude and behavior find an incidence of sexual dysfunction ranging from 14–66%. Sexual dysfunction may be more common
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