Results 151 to 160 of about 134,853 (213)

Exploring the HIV Disclosure Patterns to Sexual Partners and Associated Factors Among HIV-Positive Adults in Sheger City, Ethiopia: A Multicenter Study. [PDF]

AIDS Res Treat
Regea Gelassa F, Hailu Shene M, Tiki Kejela T, Zewdu Gemmeda T, Andasha Fana E, Atomsa L, Benti Muse T.   +6 more
europepmc   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Transmission of yeast and bacterial symbionts between sexual partners in <i>Drosophila suzukii</i> and <i>Drosophila melanogaster</i>. [PDF]

R Soc Open Sci
Guilhot R, Xuéreb A, Fellous S.
europepmc   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

Sociodemographic associated factors with non-disclosure of HIV sero-status to sexual partners in Maputo, Mozambique. [PDF]

Sci Rep
Mudender F, Paredes Z, Maiela A, Vio F, Amane G, Mamudo A, Uamir R, Paude E, Couto A, Bello S, Ruano M, Wate J, McDowell M, Chwastiak L, Lane J, Nacarapa E.   +15 more
europepmc   +1 more source

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

HIV status disclosure to male sexual partners and predictors among young women living with HIV in rural Uganda: a cross-sectional study. [PDF]

Ther Adv Reprod Health
Kumakech E, Benyumiza D, Musinguzi M, Inzama W, Doryn E, Okello J, Kabiri L, Berggren V, Ogwal-Okeng JW.   +8 more
europepmc   +1 more source

Towards a Compositional Framework for Describing Human Phenotypes

Advanced Science, EarlyView.
The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu, Yunchao Ling, Xinyue Hu, Wei Chen, Rong Zhou, Xinhao Zhuang, Yanfeng Jiang, Jialu Zhao, Xingdong Chen, Jingchun Luo, Li Jin, Guoqing Zhang   +11 more
wiley   +1 more source

HIV incidence and its associated factors among young adults with multiple sexual partners in Maputo, Mozambique: a vaccine preparedness study. [PDF]

BMC Public Health
Macicame I, Bhatt N, Viegas E, Yates A, Nwoga C, Chissumba RM, Monteiro V, Imbach M, Milazzo M, Li Q, Schech S, Mebrahtu T, Eller LA, Swann E, Michael NL, Robb ML, Crowell TA, Polyak CS, Jani I, RV363 Study Group.   +19 more
europepmc   +1 more source