Results 111 to 120 of about 1,897,497 (307)

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia

Advanced Science, EarlyView.
The gut microbiota organizes into two robust association patterns linked to colorectal neoplasia risk. Topological shifts in microbial networks are associated with metabolite alterations and may shape host responses during disease development. ABSTRACT Alterations of gut microbial communities impact health.
Kai Song, Youwen Qin, Jiahui Luo, Liping Liu, Chenyu Luo, Yinbin Qiu, Yiyi Zhong, Huanzi Zhong, Kui Wu, Meng Ni, Dong Wu, Min Dai, Shida Zhu, Hongda Chen   +13 more
wiley   +1 more source

Communication and closeness versus sexual satisfaction of spouses

Fides et Ratio
The subject of the presented analyzes is communication and closeness versus sexual satisfaction among married people. The aim of the research was to check the connection between the independent variables–communication and closeness and the dependent ...
Małgorzata Weryszko
doaj   +1 more source

The Satisfaction Congruency Theory: The Case of Sexual Satisfaction

Recoletos Multidisciplinary Research Journal, 2014
The culture of putting primacy to pleasure and satisfaction is gaining headway not only in the Philippines but in the world as well. It is slowly building a counter culture to the Catholic beliefs that the missionary friars propagated. Religion taught the people that sex is sacred, and rendered it as taboo in this culture.
Tonette M. Villanueva, Jessica M. Avenido, Juanito B. Aliño Jr., Melvin R. de Castro   +3 more
openaire   +1 more source

Sexual Role Functioning, Sexual Satisfaction, and Intimacy After Surviving Burn Injuries: A Scoping Review of Associated Factors, Screening Tools, and Burn Care Staff Preparedness. [PDF]

Although concerns regarding intimacy abound among burn survivors, these are often not captured during rehabilitation. Considering that sexuality remains a part of humans suggests a critical need to pay attention to this aspect.
Kuug, AK, Wong, AKC, Wong, Frances Kam Yuet, Baffour, PK, Bayuo, J, Kuug, A, Baffour, Prince Kyei, Bayuo, Jonathan, Kuug, Anthony Kolsabilik, Wong, FKY, Wong, Arkers Kwan Ching   +10 more
core   +1 more source

Transformer‐Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy‐Treated Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study developed ECOS‐Net, a transformer‐based multitask framework integrating CT‐derived habitat and 2.5D deep learning features to simultaneously predict early disease control and overall survival in hepatocellular carcinoma patients treated with immune checkpoint inhibitors.
Xiaona Fu, Yusheng Guo, Bingxin Gong, Jie Lou, Ning Wang, Xuejun Chen, Hongtao Hu, Rundong Wang, Xiaofang Guo, Shanmei Li, Yangyang Xie, Shichao Long, Mengsi Li, Shubo Pan, Wen Shen, Zhaogang Zhang, Zifang Song, Pengchen Liang, Xiaoyun Liang, Peng Sun, Guilin Zhang, Shanshan Jiang, Jinxiang Zhang, Lian Yang   +23 more
wiley   +1 more source

Turning Down, Tuning In: How Mindfulness Shapes Sexual Rejection, Relationship Satisfaction, and Sexual Satisfaction [PDF]

The Journal of Sex Research
Sexual rejection is a challenging interpersonal experience in intimate relationships. The present research examined how mindfulness relates to the use of different sexual rejection strategies across three studies with complementary methodologies: cross-sectional (Study 1), experimental (Study 2) and longitudinal (Study 3).
Jiaxuan Du, Kiersten Dobson, Emily A. Impett, Sarah C. E. Stanton   +3 more
openaire   +2 more sources

Context‐Dependent Inverse Association of Glucose–Lipid Metabolic Status With Anemia: Evidence From Multinational Multicohort Analyses

Advanced Science, EarlyView.
Across six multinational cohorts, higher triglyceride–glucose index values are consistently associated with lower prevalent and incident anemia, despite their established adverse cardiometabolic significance. This inverse relationship varies across inflammatory, cardiovascular, and renal contexts, suggesting that glucose–lipid metabolic status carries ...
Guosong Jiang, Xinxing Wang, Lianfeng Xie, Wenna Ding, Yingyong Yin, Mei Yao, Zhibo Cui, Kaiqiang Tang, Lijie Zhong, Zhi Wang, Jia Wang, Lei Lei, Xiaoxiao Qu, Chi‐E. Qiu   +13 more
wiley   +1 more source

Targeting Macrophage‐Mediated Lymphatic Immunosuppression to Prevent Tumor Recurrence After Microwave Ablation

Advanced Science, EarlyView.
Incomplete microwave ablation induces animmunosuppressive microenvironment in tumor‐draining lymph nodes. An albumin‐based lipoprotein nanosystem enables coordinated delivery of immunomodulators to tumor‐draining lymph nodes and residual tumors, reverses post‐ablation immunosuppression, suppresses residual tumor growth, and promotes durable antitumor ...
Xuexia Shan, Yuting Shen, Xiaodong Hou, Fengshan Jin, Shaoyue Li, Weichen Xu, Weiwei Ren, Xiaowan Bo, Qiuyan Li, Shuo Liu, Weifan Hao, Chengzhong Peng, Huixiong Xu, Liping Sun, Wenwen Yue   +14 more
wiley   +1 more source

Sexual offender risk assessment strategies: is there a convergence of opinion yet? [PDF]

, 2006
While there is no convergence of opinion in the academic literature, many clinicians have already adopted a convergent approach to risk assessment, whether through deliberate adoption of complementary instruments or through informal clinical modification
Boer, Douglas Pieter
core