Results 111 to 120 of about 837,519 (281)

Sexual selection and hermaphroditic organisms: Testing theory

Current Zoology, 2013
Sexual selection is widespread if not ubiquitous in hermaphroditic organisms. Although many phenomena that have been described as sexual selection in gonochores, (e.g. harem polygamy, multiple mating, elaborate courtship, even secondary sexual characters)
Janet L. LEONARD
doaj  

Rapid male plumage evolution drives sexual dichromatism in Ficedula flycatchers

Avian Research
Sexual dichromatism represents a major form of phenotypic differentiation between the sexes in birds, and its evolution is likely shaped by the interplay between sexual and natural selection.
Lijun Gao, Yueyao Wang, Zheng Li, Lu Dong   +3 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Sexual dimorphism in the South American water snake Helicops polylepis (Serpentes: Dipsadidae)

Phyllomedusa: Journal of Herpetology, 2021
Sexual selection, fecundity selection and ecological divergence have been the main explanations proposed for the origin and maintenance of sexual dimorphism.
Isla Carol Marialva Camargo, Jackeline Cristina Palma Veras, Síria Ribeiro, Ricardo A. Kawashita-Ribeiro, Rafael de Fraga, Alfredo P. Santos Junior   +5 more
doaj  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Risk of Population Extinction from Periodic and Abrupt Changes of Environment

, 2008
A simulation model of a population having internal (genetic) structure is presented. The population is subject to selection pressure coming from the environment which is the same in the whole system but changes in time.
Andrzej Pękalski, Bak, Bena, Bokowska, Bürger, Chowdhury, Drossel, Droz, Fraser, Goodman, Hall, Higgs, La Barbera, Lande, Lande, Marcel Ausloos, Murray, Pawlikowski, Pease, Rikvold, Roberts, Shaffer, Shnerb, Shnerb, Stauffer, Vanderwalle, Zawierta   +26 more
core   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

The origins and drivers of sexual size dimorphism in sharks

Ecology and Evolution
While sexual size dimorphism (SSD) is abundant in nature, there is huge variation in both the intensity and direction of SSD. SSD results from a combination of sexual selection for large male size, fecundity selection for large female size and ecological
Joel H. Gayford, Phillip C. Sternes
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source