Results 91 to 100 of about 221,310 (303)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
The relationship between sexual selection and sexual conflict [PDF]
, 2014 Evolutionary conflicts of interest arisewhenever genetically different individuals interact and their routes to fitness maximization differ.
Kokko, H +3 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The function and evolutionary ecology of intra-sexual aggression in drosophila melanogaster
, 2021 Across the animal kingdom, competition for reproductive resources often results in intra-sexual aggressive contests. The extent to which individuals engage in aggression varies in response to ecological conditions.
Edmunds, Danielle
core +2 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
G3: Genes, Genomes, Genetics, 2020 Theoretical work predicts that sexual selection can enhance natural selection, increasing the rate of adaptation to new environments and helping purge harmful mutations.
Christopher H. Chandler +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Ecology, sexual selection and speciation
, 2011 The spectacular diversity in sexually selected traits among animal taxa has inspired the hypothesis that divergent sexual selection can drive speciation.
Ole Seehausen +3 more
core +1 more source
Song post exposure, song features, and predation risk [PDF]
, 2005 Male birds use song to attract mates and deter other males, but in doing so, they also attract the attention of predators and parasites. Such viability costs are inherent in reliable signals, potentially causing females to prefer mates that display from ...
J. T. Nielsen +5 more
core +1 more source