Results 51 to 60 of about 837,519 (281)

Evidence for the stress-linked immunocompetence handicap hypothesis in humans [PDF]

, 2012
Secondary sexual traits that develop under the action of testosterone, such as masculine human male facial characteristics, have been proposed to signal the strength of the immune system due to the sex hormone's immunosuppressive action.
Kecko, Sanita, Kivleniece, Inese, Krama, Tatjana, Krams, Indrikis, Moore, Fhionna R., Rantala, Markus J., Skrinda, Ilona   +6 more
core   +4 more sources

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Determinants of male fitness: disentangling intra- and inter-sexual selection. [PDF]

, 2008
Both intra- and inter-sexual selection may crucially determine a male's fitness. Their interplay, which has rarely been experimentally investigated, determines a male's optimal reproductive strategy and thus is of fundamental importance to the ...
Andersson, Bateman, Bauwens, Boudjemadi, Boudjemadi, Bradbury, Censky, Clobert, Cooper, Depeiges, Emlen, Fitze, Gross, Halliday, Heulin, Janzen, Laloi, Lande, Le Galliard, Le Galliard, Le Galliard, Le Galliard, LeBas, LeBas, Lecomte, Lessells, Littell, Léna, Marshall, Massot, Olsson, Olsson, Olsson, Orrell, Quinn, Richard, Shine, Shuster, Siegel, Tokarz   +39 more
core   +3 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

The Influence of Signaling Conspecific and Heterospecific Neighbors on Eavesdropper Pressure [PDF]

, 2019
The study of tradeoffs between the attraction of mates and the attraction of eavesdropping predators and parasites has generally focused on a single species of prey, signaling in isolation.
Benson, Christopher S., Caldwell, Michael S., Lam, Tiffany L., Logue, David M., Pickering, Oliver H., Trillo, Paula A.   +5 more
core   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Understanding the evolution of ecological sex differences: Integrating character displacement and the Darwin‐Bateman paradigm

Evolution Letters, 2019
Sex differences in selection arise for at least two possible reasons: (1) differences originating from anisogamy—the Darwin‐Bateman paradigm—and (2) competition‐driven ecological character displacement (ECD), agnostic of anisogamy.
Stephen P. De Lisle
doaj   +1 more source

Characterization of spotted hyena, Crocuta crocuta microsatellite loci [PDF]

, 2003
We have isolated 10 polymorphic microsatellite loci in the spotted hyena,Crocuta crocuta.The loci displayed between eight and 14 alleles in a minimum of 12 individuals tested.
Altschul, Armour, Carolsyn Greig, Christian Schlötterer, Deborah A. Dawson, Diethard Tautz, East, Giles F. Horsfield, Heribert Hofer, Kerstin Wilhelm, Louise K. Gentle, Marion East, Mills, Promega, Rassmann, Rozen, Sambrook, Slattery, Terry Burke   +18 more
core   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Dynamics of multiple sexual signals in relation to climatic conditions [PDF]

, 2007
Question: Can trait-specific phenotypic plasticity in response to annual environmental variation lead to changes in the strength of sexual selection through the relative expression of sexual ornaments at the population level?
Garamszegi, László Zsolt, Hargitai, Rita, Hegyi, Gergely, Rosivall, Balázs, Szöllösi, Eszter, Török, János   +5 more
core