Results 51 to 60 of about 679,834 (286)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Self-perception of sexual life and associated factors: a population study conducted in women aged 50 or more years [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2013
PURPOSE: To evaluate the prevalence of women aged 50 years or more who are sexually active and their self-perception with respect to their sexual lives. Associated factors were also assessed.
Ana Lúcia Ribeiro Valadares, Vanessa de Souza Santos Machado, Lúcia Costa-Paiva, Maria José Osis, Maria Helena de Sousa, Aarão Mendes Pinto-Neto   +5 more
doaj   +1 more source

Autoconcepto, ansiedad social y sintomatología depresiva en adolescentes españoles según su orientación sexual [PDF]

, 2012
Non-heterosexual adolescents are at risk for developing emotional problems because of social stigma and adaptation difficulties. In Spain there are hardly any data on the state of this population during adolescence. The objective of this study was to ex-
Ballester-Arnal, Rafael, Espada Sánchez, José Pedro, Morales Sabuco, Alexandra, Orgilés Amorós, Mireia   +3 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Depression and self-concept in girls with perception of pubertal onset [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2013
PurposeEarly pubertal timing in girls is associated with psychological and behavioral problems. This study aimed to evaluate the psychological features of girls who perceived breast development beginning by analyzing their depression levels and self ...
Ji Hyeon Yang, Sang Woo Han, Chan Woo Yeom, Yong Jun Park, Wha Su Choi, Ji Young Seo, Young Jin Koo   +6 more
doaj   +1 more source

Perilaku Seksual Pranikah pada Mahasiswa [PDF]

, 2013
Meningkatnya perilaku seksual pranikah berdampak pada kehamilan di luar nikah. Masalahpenelitian adalah faktor apakah yang berhubungan dengan perilaku seksual pranikahmahasiswa siswa di STIKes Medistra Indonesia Jakarta pada tahun 2011.
Irmawaty, L. (Lenny)
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Relation between Sexual Self-Concept and Sexual Distress in Women with Multiple Sclerosis Who Referred To Shahid Sadoughi Hospital of Yazd In 2017

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2019
Introduction: The prevalence of sexual disorders is high among women with multiple sclerosis in the world. Sexual dysfunction is considered as one of the effective psychological factors on self-concept sexual function.
Fatemeh Zarei Mahmoud Abadi, Shayesteh Salehi, Mahsa Sadat Mousavi   +2 more
doaj  

Developing sexual competence? Exploring strategies for the provision of effective sexualities and relationships education [PDF]

, 2008
School-based sexualities and relationships education (SRE) offers one of the most promising means of improving young people's sexual health through developing 'sexual competence'. In the absence of evidence on whether the term holds the same meanings for
Aggleton P., Fine M., Giddens A., Harding J., Hirst J., Hirst J., Ingham R., Julia Hirst, Kippax S., Kvale S., Measor L., Measor L., Morris R. W., Smith D. E., Trudell B. N., Westwood J.   +15 more
core   +1 more source