Results 41 to 50 of about 29,197 (258)

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Human Sexual Size Dimorphism in Early Pregnancy [PDF]

American Journal of Epidemiology, 2007
Sexual size dimorphism is thought to contribute to the greater mortality and morbidity of men compared with women. However, the timing of onset of sexual size dimorphism remains uncertain. The authors determined whether human fetuses exhibit sexual size dimorphism in the first trimester of pregnancy.
Radek, Bukowski, Gordon C S, Smith, Fergal D, Malone, Robert H, Ball, David A, Nyberg, Christine H, Comstock, Gary D V, Hankins, Richard L, Berkowitz, Susan J, Gross, Lorraine, Dugoff, Sabrina D, Craigo, Ilan E, Timor-Tritsch, Stephen R, Carr, Honor M, Wolfe, Mary E, D'Alton   +14 more
openaire   +2 more sources

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Sexual dimorphism in Apfelbeckia insculpta (L. Koch, 1867) (Myriapoda: Diplopoda: Callipodida) [PDF]

Archives of Biological Sciences, 2017
Apfelbeckia insculpta (L. Koch, 1867) is one of the largest European millipedes and an endemic species of the Balkan Peninsula. We present data on sexual dimorphism in size and body proportions obtained from 179 adult specimens of this species ...
Ilić Bojan S., Mitić Bojan M., Makarov Slobodan E.   +2 more
doaj   +1 more source

THE ORIGINS OF SEXUAL DIMORPHISM IN BODY SIZE IN UNGULATES [PDF]

Evolution, 2002
Jarman (1974) proposed a series of relationships between habitat use, food dispersion, and social behavior and hypothesized a series of evolutionary steps leading to sexual dimorphism in body size through sexual selection in African antelope species. The hypothesis states that sexual size dimorphism evolved in a three-step process. Initially, ancestral
Pérez-Barbería, F.J., Gordon, I.J., Pagel, M.   +2 more
openaire   +3 more sources

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Sexual dimorphism in the Chinese endemic species Pachyhynobius shangchengensis Fei, Qu and Wu, 1983 (Urodela: Hynobiidae) [PDF]

PeerJ, 2019
Sexual dimorphism (SD) is a widespread phenomenon in most vertebrate species and is exhibited in a myriad of ways. In amphibians, sexual size dimorphism, in which females are larger than males, is the most common type, and sexual shape dimorphism varies ...
Jianli Xiong, Baowei Zhang, Qiangqiang Liu, Tao Pan, Jianping Gou   +4 more
doaj   +2 more sources

Invasive American Bullfrogs Age, Body Size, and Sexual Size Dimorphism Geographical Variation in Northwestern China

Diversity, 2022
Invasive species impact both the local biota and human economies and are a very serious threat to biodiversity. The American bullfrog was initially introduced into northwestern China and many other sites for aquacultural purposes. Then, the frogs escaped
Feng Xu, Jun Li, Weikang Yang
doaj   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Habitat‐Driven Sexual Dimorphism in Triplophysa strauchii Between Oxbow Lake and Stream: A Geometric Morphometric Analysis

Ecology and Evolution
Sexual dimorphism is widespread among fish species, yet the ecological factors shaping this phenomenon remain poorly understood. Using traditional morphometric analyses of 319 specimens together with geometric morphometrics, this study examined sexual ...
Yan Li, Ya‐Han Meng, Wei‐Zhen Gao, Lei Shi   +3 more
doaj   +1 more source