Results 101 to 110 of about 487,907 (301)

CD207‐Positive Dendritic Cells Promote Emphysema Through CD8+ T Cell Pathway in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
CD207+ dendritic cells (DCs) drive emphysema by promoting CD8⁺ T cell cytotoxicity via Birbeck granule‐dependent MHC‐I antigen presentation. This DC subset is expanded by cigarette smoke‐induced oxidative stress, which triggers granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) release from airway epithelium.
Shurui Xuan, Yunhui Wu, Feng Liu, Heng Fu, Yaqi Meng, Yingwei Ou, Xijing Yuan, Ian M. Adcock, Man Jia, Xiaoning Zeng, Xin Yao   +10 more
wiley   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

The new face of monkeypox virus: an emerging global emergency

New Microbes and New Infections, 2022
Nityanand Jain, Edouard Lansiaux, Raimonds Simanis   +2 more
doaj   +1 more source

Mate limitation, recurrent epidemic outbreaks, and the coexistence of sexual and asexual plant parasites [PDF]

, 2014
To date, relatively few studies have focused on the effects of sex on population dynamics. Previous models found that sexual reproduction may either dampen population fluctuations or accentuate population fluctuations, depending on mating system notably.
Hamelin, Frédéric, Lemesle, Valérie, Mailleret, Ludovic, Ravigné, Virginie   +3 more
core  

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, EarlyView.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

The evolving mpox threat (2022-2024): clade dynamics, immune evasion, and escalating global health challenges

Frontiers in Cellular and Infection Microbiology
The 2022–2024 global Mpox outbreak, declared a Public Health Emergency of International Concern, marks a pivotal shift in the virus’s epidemiology, extending beyond its traditional endemic regions in Africa. This review provides a comprehensive synthesis
Muhammad Irfan Khan, Ahmed A. Saleh, Ahmed A. Saleh, Rahmat Ali, Rifat Ullah Jan, Jie Gu, Ji Dejun   +6 more
doaj   +1 more source

Hepatitis B virus infection among sexually active individuals in Nigeria: a cross-sectional study

The Pan African Medical Journal, 2018
INTRODUCTION: Hepatitis B virus (HBV) infection is a major health challenge in sub-Saharan African countries. Chronic HBV infection is a risk factor for severe disease progression.
Yewande Nejo, Adedayo Omotayo Faneye, Babatunde Olusola, Solomon Bakarey, Adebowale Olayinka, Babatunde Motayo, PERVI Study Group   +6 more
doaj   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Sexual transmission of murine papillomavirus (MmuPV1) in Mus musculus

eLife, 2019
Human papillomaviruses (HPVs) are the most common sexually transmitted infectious agents. Because of the species specificity of HPVs, study of their natural transmission in laboratory animals is not possible.
Megan E Spurgeon, Paul F Lambert
doaj   +1 more source

Estimating infectious disease parameters from data on social contacts and serological status

, 2010
In dynamic models of infectious disease transmission, typically various mixing patterns are imposed on the so-called Who-Acquires-Infection-From-Whom matrix (WAIFW).
Anderson, Beutels, Burnham, Cauchemez, Diekmann, Edmunds, Edmunds, Eurostat, Farrington, Farrington, Ferguson, FOD Economie Afdeling Statistiek, Garnett, Greenhalgh, Halloran, Hens, Hens, Hens, Kanaan, Longini, Mammen, Melegaro, Mikolajczyk, Mossong, Mossong, Nardone, Ogunjimi, Schwarz, Van Effelterre, Wallinga, Whitaker, Wood   +31 more
core   +1 more source