Results 111 to 120 of about 487,907 (301)

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

Preliminary Studies on Immune Response and Viral Pathogenesis of Zika Virus in Rhesus Macaques

Pathogens, 2018
Zika Virus (ZIKV) is primarily transmitted through mosquito bites. It can also be transmitted during sexual intercourse and in utero from mother to fetus.
Shawna M. Woollard, Omalla A. Olwenyi, Debashis Dutta, Rajnish S. Dave, Saumi Mathews, Santhi Gorantla, Noel Johnson, Luis Giavedoni, Robert B. Norgren Jr., Siddappa N. Byrareddy   +9 more
doaj   +1 more source

Understanding the role of sexual transmission in the spread of ZIKA virus using an individual-based interconnected population model [PDF]

, 2019
Citation: Tanver, F., Lee, C., Mcvey, D., & Scoglio, S. (2018). Understanding the role of sexual transmission in the spread of ZIKA virus using an individual-based interconnected population model. Pre-Print, Unpublished Manuscript.Zika virus has affected
Cohnstaedt, Lee W., Ferdousi, Tanvir, McVey, D. S., Scoglio, Caterina M.   +3 more
core  

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Transmission of yeast and bacterial symbionts between sexual partners in Drosophila suzukii and Drosophila melanogaster

Royal Society Open Science
Sexually transmitted symbionts can substantially affect the performance and evolution of their hosts. From a pest control perspective, the sexually transmitted microorganisms of insects can be considered powerful biological control agents or probiotics ...
Robin Guilhot, Anne Xuéreb, Simon Fellous   +2 more
doaj   +1 more source

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

Unsafe Sex, AIDS, and Development [PDF]

Much of Africa has been ravaged by the AIDS epidemic. There, heterosexual contact is the primary mode of transmission for the HIV virus. Even when access to condoms is good and their price low, a large fraction of young Africans continue to engage in ...
Bhattacharya, Joydeep, Bunzel, Helle, Qiao, Xue   +2 more
core  

Tim1 Deficiency Mediates Gestational Hyperglycemia‐Related Syncytiotrophoblast Dysfunction and Fetal Growth Restriction

Advanced Science, EarlyView.
Hyperglycemia during pregnancy impairs the fusion of trophoblast cells into syncytiotrophoblasts, leading to fetal growth restriction. This impaired fusion is mediated by Tim1 downregulation via hyperglycemia‐induced ROS. Antioxidant therapy during pregnancy promotes syncytiotrophoblast formation by upregulating Tim1 expression, thus alleviating fetal ...
Junsen She, Rui Liu, Chen Fang, Shuyu Zhang, Yizhi Hu, Fei Guo, Yuhang Long, Mengzhen Ding, Haiyan Wu, Bokang Zhou, Zexin Yang, Ying Jiang, Jianzhong Sheng, Ling Gao, Hefeng Huang   +14 more
wiley   +1 more source

Sexual Transmission of Zika Virus and Persistence in Semen, New Zealand, 2016

Emerging Infectious Diseases, 2016
Jay Harrower, Tomasz Kiedrzynski, Simon Baker, Arlo Upton, Fahimeh Rahnama, Jill Sherwood, Q. Sue Huang, Angela Todd, David Pulford   +8 more
doaj   +1 more source

Risk of sexual transmission of HIV in the context of viral load suppression. [PDF]

Can Commun Dis Rep, 2023
Djiadeu P, Begum H, Sabourin S, Gadient S, Archibald C, LeBlanc MA, Chittle A, Fleurant A, Cox J.   +8 more
europepmc   +1 more source