Advanced Science, EarlyView.This study identifies the circadian transcription factor CLOCK (CLK) as a key regulator of oxidative stress resistance in fruit flies. CLK controls immune responses by driving rhythmic transcription of an RNA‐binding protein‐Achilles (ACHL) in the fly brain, which post‐transcriptionally represses the NF‐κB homolog Relish, limiting immune activation and
Xu Liu +7 more
wiley +1 more source
Advanced Science, EarlyView.Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han +16 more
wiley +1 more source
Knowledge, attitudes, and beliefs about sexual violence, and the implementation of sexual violence prevention programming: Survey of faculty at seven universities in Vietnam [PDF]
Daniel J. Whitaker +5 more
openalex +1 more source
Advanced Science, EarlyView.This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li +22 more
wiley +1 more source
A mental health emergency: A clinical and cultural response to sexual violence in the Democratic Republic of the Congo. [PDF]
Glob Ment Health (Camb)Bapolisi A.
europepmc +1 more source
Advanced Science, EarlyView.Prenatal dexamethasone exposure (PDE) persistently upregulates hepatic CYP3A1/CYP2B1 in offspring via glucocorticoid receptor (GR) activation. In vivo and in vitro studies show GR promotes P300/CBP binding to the constitutive androstane receptor (CAR) promoter, sustaining histone acetylation (H3K9/K27ac) and enhancing CYP expression. The GR–CAR pathway
Xiaoxiang Sun +9 more
wiley +1 more source
Medical mistrust among diverse survivors of sexual violence: implications for primary health care delivery and engagement. [PDF]
BMC Prim CareAnderson KM +3 more
europepmc +1 more source
Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels
Advanced Science, EarlyView.A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu +10 more
wiley +1 more source
Case study guided development of an implementation science framework and checklist for campus sexual violence intervention. [PDF]
BMC Glob Public HealthFielding-Miller R +8 more
europepmc +1 more source
Sexual Violence beyond Reasonable Doubt: Using Pattern Evidence and Analysis for International Cases [PDF]
, 2010 Xabier Agirre Aranburu
openalex +1 more source