Results 211 to 220 of about 2,215,465 (390)

SETD1A Regulates Glycolysis and Senescence of Nucleus Pulposus Cells via H3K4me3–HELZ2/PPARα‐HIF1α Axis to Drive Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
SETD1A is a key epigenetic regulator in NPCs during IDD. In normal NPCs, it sustains H3K4me3–HELZ2/PPARα–HIF1α signaling to maintain glycolytic energy metabolism and proliferation. In degenerated NPCs, reduced SETD1A disrupts this axis, impairing glycolysis and accelerating senescence, highlighting a promising therapeutic target for IDD.
Jiawei Fu   +11 more
wiley   +1 more source

Addressing Sexual Violence Against Persons with Disabilities in Belgium. [PDF]

open access: yesHealthcare (Basel)
Fomenko E   +3 more
europepmc   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

open access: yesAdvanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li   +13 more
wiley   +1 more source

Sexual and reproductive health and rights in humanitarian crises at ICPD25+ and beyond: consolidating gains to ensure access to services for all

open access: yesSexual and Reproductive Health Matters, 2019
Shirin Heidari   +2 more
doaj   +1 more source

Technology-Facilitated Online Sexual Violence, Consent Negotiation, and Coping Among Adult Women: A Qualitative Study. [PDF]

open access: yesHealthcare (Basel)
Martínez-Díaz A   +7 more
europepmc   +1 more source

The Role of Social Media Among Women Survivors of Sexual Violence

open access: diamond
Sartika Sari Wardanhi Dh Pasha   +2 more
openalex   +2 more sources

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