Results 251 to 260 of about 762,386 (353)

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Warm family of origin is associated with earlier disclosure of sexual abuse. [PDF]

Eur J Psychotraumatol
Barge C, Sijbrandij M, Both S, van Ditzhuijzen J, Bicanic I.   +4 more
europepmc   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

The role of childhood traumas on father-child sexual communication language: Self-esteem, social anxiety and sexual education. [PDF]

PLoS One
Güngör I, Artan IZ.
europepmc   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Cost-benefit analysis of adolescent HIV/STI prevention and comprehensive sexuality education interventions in Cambodia: a modelling study. [PDF]

BMJ Public Health
Wickramaarachchi T, Phon V, Bernklau S, Sladden T, Martin-Hughes R, Scott N.   +5 more
europepmc   +1 more source

Cars2‐Mediated Cysteine Catabolism Drives Brown Fat Development and Thermogenesis Through Persulfidating EBF2

Advanced Science, EarlyView.
We demonstrate that Cars2, a cysteine catabolic enzyme in mouse iBAT, is critical for cold tolerance and brown adipocyte differentiation. Through its CPERS activity, Cars2 produces CysSSH/H2S to induce EBF2 persulfidation, promoting its interaction with PPARγ and BRG1 to enhance thermogenic gene expression.
Xin Peng, Hongyong Song, Yin Long, Kaimin Wu, Yinkun Fu, Wenkai Zhou, Wenyan Li, Zhe Shi, Xu‐Yun Zhao   +8 more
wiley   +1 more source

How nurses address psychosocial needs in patients with advanced heart or lung failure: a qualitative interview study. [PDF]

BMC Nurs
van Oirschot J, Noijons ED, Merten H, Onwuteaka-Philipsen BD, Ockhuijsen HDL, Vervoort SCJM, Jongerden IP.   +6 more
europepmc   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

From clinics to classrooms: physicians play an essential role in transforming comprehensive sexuality education. [PDF]

Reprod Health
Jayasinghe Y, Grimstad FW, Simms-Cendan J, Rome ES, Tyson N, Labovsky M, Alonso MMP, Torres A, Nižňanská Z, Azurah AGN, M Med BI, Lijtenstein M, Oizerovich S, Perrotta GV, MacDougall J, Drejza M, Gelin M, International Federation of Paediatric, Adolescent Gynaecology (FIGIJ) Reproductive Justice Committee.   +18 more
europepmc   +1 more source