Results 41 to 50 of about 108,659 (269)
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer
Molecular Oncology, EarlyView.Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
HTS Teologiese Studies/Theological StudiesThe 19th-century missionary literary genre provides us with a window into how the missionaries viewed African cultural systems, such as polygamy. In their minds, polygamy was one of the obstacles to converting Africans to Christianity. Baptism functioned
Itumeleng D. Mothoagae, Themba Shingange
doaj +1 more source
Between Needs and Taboos: Sexuality and Reproductive Health Education for High School Students
Makara Journal of Health Research, 2013 This paper examines reproductive health and sexuality education for adolescents that has been conducted by government and non-government at the high school level.
Diana Teresa Pakasi, Reni Kartikawati
doaj +1 more source
“And the House Burned Down”: HIV, Intimacy, and Memory in Danez Smith’s Poetry
Open Cultural Studies, 2023 Danez Smith’s [insert] boy (2014) not only bears witness to the intricacy of the intersection between queerness and Blackness in the United States of the twenty-first century, but also illustrates an overcoming of multiple forms of oppression through ...
Juncosa Toni R.
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Evaluation of a Formative Intervention on Sexuality and Gender for Early Childhood Education Teachers [PDF]
, 2022 Thaís Blankenheim +2 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source