Results 51 to 60 of about 640,334 (365)

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

Comprehensive Sexuality Education [PDF]

open access: yes, 2008
Healthy Teen Network recommends and encourages the teaching of developmentally and age-appropriate comprehensive sexuality education, as it holds the greatest hope for reducing the risk of sexually transmitted infections (STIs) and unintended pregnancy ...

core  

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Sexual Interactions and Sexual Infidelity [PDF]

open access: yesThe Journal of Ethics, 2021
AbstractThis paper establishes what constitutes a sexual interaction between two or more people. It does this by first defining a sexual activity as one in which the agent intends to satisfy a sexual desire (i.e. a desire for sexual pleasure). To understand what it means to engage in a sexual activity with another person, it draws from Bratman’s ...
openaire   +4 more sources

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

open access: yesMolecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau   +9 more
wiley   +1 more source

Queer Farmers: Sexuality and the Transition to Sustainable Agriculture [PDF]

open access: yes, 2016
Intimate relationships are foundational to farm viability. Such relationships affect how farmers share tasks, earn income, and access land, yet the role of sexuality and heteronormativity in agriculture remains understudied.
Leslie, Isaac
core   +2 more sources

Evaluation of a school based comprehensive sexuality education program among very young adolescents in rural Uganda [PDF]

open access: yes, 2019
Background: Limited research has been conducted on the effectiveness of sexuality education for very young adolescents (VYAs) ages 10-14 years in Sub-Saharan Africa.
Bruce, Katherine   +9 more
core   +2 more sources

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

Sexuality and Reproduction [PDF]

open access: yes, 2004
No abstract ...
Church, Sarah, Earle, Sarah
core  

Lesbian and bisexual women's experiences of sexuality-based discrimination and their appearance concerns [PDF]

open access: yes, 2012
Lesbian and bisexual women frequently experience sexuality-based discrimination, which is often based on others' judgements about their appearance. This short article aims to explore whether there is a relationship between lesbian and bisexual women's ...
Bower J.   +29 more
core   +1 more source

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