Results 61 to 70 of about 760,667 (387)

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Lesbian Love Sonnets: Adrienne Rich and Carol Ann Duffy [PDF]

open access: yes, 2017
Our conceptualization of sexuality is rooted in gender. Modern, western society defines sexuality as which genders one is and is not attracted to—often appearing as a binary between homosexuality and heterosexuality.
Seiler-Garman, Robin
core   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

open access: yesMolecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau   +9 more
wiley   +1 more source

Bodyspace at the pub: sexual orientations and organizational space [PDF]

open access: yes, 2014
In this article we argue that sexuality is not only an undercurrent of service environments, but is integral to the way that these workspaces are experienced and negotiated.
Dale K.   +8 more
core   +1 more source

Evaluating the impact of a medical school cohort sexual health course on knowledge, counseling skills and sexual attitude change

open access: yesBMC Medical Education, 2021
Background Sexual health is generally considered an integral part of medical and allied healthcare professional training. However, many medical schools do not offer this as a mandatory curriculum, or minimize it.
Michael W. Ross   +3 more
doaj   +1 more source

Sexual Interactions and Sexual Infidelity [PDF]

open access: yesThe Journal of Ethics, 2021
AbstractThis paper establishes what constitutes a sexual interaction between two or more people. It does this by first defining a sexual activity as one in which the agent intends to satisfy a sexual desire (i.e. a desire for sexual pleasure). To understand what it means to engage in a sexual activity with another person, it draws from Bratman’s ...
openaire   +4 more sources

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

open access: yesMolecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef   +10 more
wiley   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

Making Bedlam: Toward a Trauma-Informed Mad Feminist Literary Theory and Praxis

open access: yesHumanities, 2023
Building on what Margaret Price describes as the “long history of positive and person-centered discourses” of the term Mad, this article seeks to offer a (re)tooling and (re)theorization of the not-so-antiquated concept of “bedlam” as part of a Mad ...
Jessica Lowell Mason
doaj   +1 more source

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