Results 71 to 80 of about 670,551 (364)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
HTS Teologiese Studies/Theological StudiesThe 19th-century missionary literary genre provides us with a window into how the missionaries viewed African cultural systems, such as polygamy. In their minds, polygamy was one of the obstacles to converting Africans to Christianity. Baptism functioned
Itumeleng D. Mothoagae, Themba Shingange
doaj +1 more source
“And the House Burned Down”: HIV, Intimacy, and Memory in Danez Smith’s Poetry
Open Cultural Studies, 2023 Danez Smith’s [insert] boy (2014) not only bears witness to the intricacy of the intersection between queerness and Blackness in the United States of the twenty-first century, but also illustrates an overcoming of multiple forms of oppression through ...
Juncosa Toni R.
doaj +1 more source
“Love in the Later Years…”: Perceptions of Sex and Sexuality in Older Indian Adults — a Qualitative Exploration [PDF]
, 2022 Debanjan Banerjee, TS Sathyanarayana Rao
openalex +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Between Needs and Taboos: Sexuality and Reproductive Health Education for High School Students
Makara Journal of Health Research, 2013 This paper examines reproductive health and sexuality education for adolescents that has been conducted by government and non-government at the high school level.
Diana Teresa Pakasi, Reni Kartikawati
doaj +1 more source
Comprehensive sexuality education (CSE) programming adaptations in response to disruptions caused by the COVID-19 pandemic [PDF]
, 2023 Ilya Zhukov +4 more
openalex +1 more source
Sexuality and the Aging Adult: The Attitude and Practice of Physicians and Nurse Practitioners [PDF]
, 2005 Background: As the population ages, many quality of life issues will generate discussion. One such issue is sexuality of the aging adult. While there is substantial documentation related to the physiology and desires of the aging adult, little is known ...
Runsvold, Susan
core +1 more source
Sex-gender-sexuality: how sex, gender and sexuality constellations are constituted in secondary schools [PDF]
, 2005 This paper explores the relationships between sex, gender, and sexuality through a series of close readings of data generated through an ethnography undertaken in a south London secondary school.
Youdell, Deborah
core +2 more sources