Results 51 to 60 of about 329,301 (347)

Changes in the cervicovaginal microbiota composition of HPV16‐infected patients after clinical treatment

open access: yesCancer Medicine, Volume 11, Issue 24, Page 5037-5049, December 2022., 2022
This study interpreted the differential profiles of cervicovaginal microbiota and CSTs between HC women and HPV16‐infected women with CIN I, CIN II/III or SCC. The relationship between HPV16 clearance and cervicovaginal microbiota composition in each disease stage before and after clinical treatments was also established.
Chao Li   +3 more
wiley   +1 more source

The Social Behavior and the Evolution of Sexually Transmitted Diseases [PDF]

open access: yes, 2002
We introduce a model for the evolution of sexually transmitted diseases, in which the social behavior is incorporated as a determinant factor for the further propagation of the infection. The system may be regarded as a society of agents where in principle anyone can sexually interact with any other one in the population. Different social behaviors are
arxiv   +1 more source

Gambling and crime: An exploration of gambling availability and culture in an English prison

open access: yesCriminal Behaviour and Mental Health, Volume 32, Issue 6, Page 389-403, December 2022., 2022
Abstract Background There is evidence that prisoners have the highest rate of problem gambling in any population, but little is known about the nature of in‐prison gambling, the motives for it or how it relates to prior gambling behaviour. Aims To investigate the prevalence and type of gambling prior to prison and the prevalence, type, and reasons for ...
Lauren Rebecca Smith   +2 more
wiley   +1 more source

Patient Perceptions of Medication Therapy for Prevention of Posttraumatic Osteoarthritis Following Anterior Cruciate Ligament Injury: A Qualitative Content Analysis

open access: yesArthritis Care &Research, EarlyView.
Objective Posttraumatic osteoarthritis (PTOA) accounts for nearly 12% of osteoarthritis incidences and often occurs after anterior cruciate ligament (ACL) tear. Ensuring the uptake of preventive treatments for PTOA requires that investigators and clinicians understand factors influencing patients to seek preventive therapies.
Lily M. Waddell   +10 more
wiley   +1 more source

Centers for Disease Control and Prevention sexually transmitted diseases treatment guidelines.

open access: yesClinical Infectious Diseases, 2007
The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention. Reprints or correspondence: Dr. Kimberly A.
K. Workowski, S. Berman
semanticscholar   +2 more sources

Role of Testosterone Signaling in Microglia: A Potential Role for Sex‐Related Differences in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du   +8 more
wiley   +1 more source

Annexin A3 Represses Endothelial Permeability and Inflammation During Sepsis via Actin Cytoskeleton Modulation

open access: yesAdvanced Science, EarlyView.
Annexin A3 (ANXA3) plays an endogenous protective role in endothelial dysfunction in sepsis by stabilizing the actin cytoskeleton, modulating cell permeability, and inhibiting pATF2/CD62E inflammatory signaling. Abstract Increased endothelial permeability and a dysregulated inflammatory response play key roles in organ damage in sepsis.
Manyu Xing   +4 more
wiley   +1 more source

Sialic Acid 4‐N‐Piperazine and Piperidine Derivatives Bind with High Affinity to the P. mirabilis Sialic Acid Sodium Solute Symporter

open access: yesChemMedChem, Volume 17, Issue 23, December 5, 2022., 2022
A new target: Bacterial sialic acid uptake inhibition is a promising strategy for the development of antibacterial drugs. In this study, we present the design, synthesis and evaluation of sialic acid 4‐piperidine and piperazine derivatives a novel compound class, which bind the SiaT from Proteus mirabilis and target a different portion of the binding ...
Tiago Bozzola   +3 more
wiley   +1 more source

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4‐Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

open access: yesAngewandte Chemie, EarlyView.
AZD0156, an ATM kinase inhibitor in clinical development, shows promising multistage antiplasmodial activity by targeting Plasmodium falciparum phosphatidylinositol 4‐kinase (PfPI4Kβ). With an improved specificity profile relative to other PfPI4Kβ inhibitors and moderate efficacy in a P.
John G. Woodland   +33 more
wiley   +2 more sources

Promiscuity and the Evolution of Sexual Transmitted Diseases [PDF]

open access: yes, 2003
We study the relation between different social behaviors and the onset of epidemics in a model for the dynamics of sexual transmitted diseases. The model considers the society as a system of individual sexuated agents that can be organized in couples and interact with each other.
arxiv   +1 more source

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