Results 111 to 120 of about 226,682 (346)

Synthesis and In Vitro Activity of Hypofuran B and Analogs Against Plasmodium Falciparum and Trypanosoma Cruzi

ChemMedChem, EarlyView.
Hypofuran B, drynaran, and a series of analogs are obtined by crossed aldol condensation from furfural dereivatives. Compunds are tested for in vitro activity agaisnt Trypanosoma cruzi and Plasmodium falciparum. Best results are obtained Against P. falciparum, with IC50 values ranging from 5,35 to 10,35 µg mL−1.
Cristiane Aparecida Franco, Jodieh Oliveira Santana Varejão, Isabela Penna Ceravolo, Victória Miranda Machado, Antoniana Ursine Krettli, Daniela de Melo Resende, Silvane Maria Fonseca Murta, Felipe Terra Martins, Eduardo Jorge Pilau, Vinícius Ribeiro Montes, Markus Kohlhoff, Eduardo V. V. Varejão   +11 more
wiley   +1 more source

Temperature variability homogenized thermal responses in an ectotherm community along a European longitudinal gradient

Ecography, EarlyView.
Climate change, through rising temperatures, greater variability, and more frequent extremes, is reshaping insect phenology and thermal niches, with profound effects for pest outbreaks. Predicting these impacts requires a clear understanding of species and communities' responses across geographic gradients.
Ruining Li, Chun‐Sen Ma, Léna Jego, Cécile Le Lann, Joan Van Baaren, Gang Ma   +5 more
wiley   +1 more source

Prevalence of primary HIV-1 drug resistance among antiretroviral-naïve individuals in Togo in 2023: a national study

Frontiers in Public Health
Monitoring pre-treatment drug resistance is a priority to assess the emergence of HIV resistance to antiretrovirals, especially in countries where the transition from dolutegravir-based regimens is already effective on a large scale.
Alassane Ouro-Medeli, Alassane Ouro-Medeli, Roméo M. Togan, Roméo M. Togan, Laetitia Serrano, Christelle Butel, Rogatien Atoun, Rogatien Atoun, Frederic Youa, Frederic Youa, Komlan Ali-Edje, Komlan Ali-Edje, Messanh Douffan, Messanh Douffan, Phyllis Ehlan, Phyllis Ehlan, Phyllis Ehlan, Kokou Tegueni, Kokou Tegueni, Romaric Amenti, Romaric Amenti, Abla Ahouefa Konou, Abla Ahouefa Konou, Mounerou Salou, Mounerou Salou, Mounerou Salou, Didier K. Ekouevi, Didier K. Ekouevi, Didier K. Ekouevi, Martine Peeters, Anoumou C. Dagnra, Anoumou C. Dagnra, Anoumou C. Dagnra   +32 more
doaj   +1 more source

Sexually transmitted infections in Poland in 2013-2018 in comparison to other European countries based on infectious diseases surveillance in Poland and in Europe

, 2022
Marta Niedźwiedzka-Stadnik, Karolina Zakrzewska   +1 more
openalex   +2 more sources

Identifying and overcoming barriers to referral in advanced heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC

European Journal of Heart Failure, EarlyView.
Barriers and solutions to referral and therapy implementation in advanced heart failure. EMR, electronic medical record; HF, heart failure; HT, heart transplantation; ICARe‐HF, integrated care for advanced heart failure; LVAD, left ventricular assist device; MCS, mechanical circulatory support; OMT, optimal medical therapy; RCT, randomized controlled ...
Guillaume Baudry, Maria Generosa Crespo‐Leiro, Clément Delmas, Federica Guidetti, Marta Jimenez‐Blanco Bravo, Federica Valente, Maja Cikes, Nicolas Girerd, Finn Gustafsson, Gianluigi Savarese, Linda W. van Laake, Loreena Hill, Anne Kathrine Skibelund, Andreas Zuckermann, Marco Metra, Kevin Damman   +15 more
wiley   +1 more source

ABC of adolescence: sexual health, contraception, and teenage pregnancy [PDF]

, 2005
Sexual health becomes a new health priority in early adolescence. The sexual health of young people is a matter of intense public concern. The adverse consequences of unsafe sexual behaviour-such as pregnancy and sexually transmitted infections (STIs)
Tripp, J., Viner, R.
core  

Sexually Transmitted Infections [PDF]

Journal of Midwifery & Women's Health, 2021
openaire   +2 more sources

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Areas of research priorities in epilepsy: A position paper of the European Reference Network for Rare and Complex Epilepsies, EpiCARE

Epilepsia Open, EarlyView.
Abstract Objective To define and articulate research priorities in epilepsy identified by the European Reference Network for Rare and Complex Epilepsies (ERN EpiCARE), addressing key unmet needs across the spectrum of rare and complex epilepsies. Methods This position paper was developed through a structured collaborative process involving patient ...
Sébile Tchaicha, Stéphane Auvin, Sándor Beniczky, Andreas Brunklaus, Lieven Lagae, Emilio Perucca, Rainer Surges, Sophie Adler, Christoph Helmstaedter, Floor Jansen, Guido Rubboli, Philippe Ryvlin, Nicola Specchio, Eugen Trinka, Ingmar Blümcke, Valentina de Giorgis, Katarzyna Kotulska, Gaetan Lesca, Masa Malenica, Amy McTague, Rima Nabbout, Rikke Steensbjerre Møller, Sandra Silva Arrieta, Isabella Brambilla, Małgorzata Kosla, Kees Braun, J. Helen Cross, Alexis Arzimanoglou   +27 more
wiley   +1 more source

Temporal Trends in the Epidemiology of Eating Disorders Between 2000 and 2022: A Danish Register Study of Their Incidence and Comorbidities

European Eating Disorders Review, EarlyView.
ABSTRACT Background Eating disorders are debilitating illnesses that often co‐occur with other psychiatric disorders and somatic diseases. Evidence indicates that the incidence of eating disorders has been increasing. We first examine the landscape of EDs over time, including the COVID‐19 period, via assessing the incidence of anorexia nervosa (AN ...
Nadia Micali, Helena L. Davies, Heidi Jeannet Graff, Laust H. Mortensen, Emilie R. Hegelund   +4 more
wiley   +1 more source