Results 241 to 250 of about 281,645 (290)

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Why Computational Photochemistry Is Challenging and Will Probably Remain So: A Quantum Chemist's Perspective

Advanced Science, EarlyView.
Computational Photochemistry has made great strides in recent decades, but the investigation of larger molecules remains a challenge due to the inherent dilemma between the increasing computational accuracy required as the molecule size increases and the inevitable explosion in computational effort.
Andreas Dreuw
wiley   +1 more source

Selectivity Filter Dynamics Define Ion Conductance and Selectivity Differences in CNG and HCN Channels

Advanced Science, EarlyView.
Cyclic nucleotide‐gated (CNG) and hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels share substantial sequence and structural similarity but differ markedly in ion conductance and K+ selectivity. Microsecond‐scale atomistic MD simulations qualitatively reproduced the conductance differences observed in single‐channel recordings and ...
Haoran Liu, Klaus Benndorf, Yessenbek K. Aldakul, Han Sun   +3 more
wiley   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Orientation‐Confinement‐Engineered Stabilization of Ferroelectricity in HfO2 toward Maximum Polarization

Advanced Science, EarlyView.
Ferroelectric phase stability in Hf₀.5Zr₀.5O2 films is enhanced by confinement to the (111) crystal orientation, as demonstrated by first‐principles calculations and experiments. Polarization approaching its maximum value is achieved through selective ferroelectric switching paths, which are further tuned by oxygen vacancies and cation doping to ...
Fatoye Sawyerr, Yongqing Sun, Zekun Zhang, Kang Jia, Shuning Lv, Qi Hu, Shu Shi, Qiushi Huang, Xie Zhang, Xiaoli Fan, Li‐min Liu, Shifeng Wen, Zheng Wen, Tengfei Cao, Jingsheng Chen   +14 more
wiley   +1 more source

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MOS-SF 36

European Journal of Psychological Assessment, 2007
The objective was to study the construct validity of the MOS SF-36 (Medical Outcome Study, short form questionnaire, version of 36 items) using structural equation modeling (SEM). Despite the widespread use of the questionnaire, several problems with the measurement model have been shown in the past, and it is highly disputable whether the computation
Güthlin, Corina, Walach, Harald
openaire   +2 more sources

Smoking and SF-36 health functioning

Preventive Medicine, 2006
To examine the association between smoking and general health as measured by the Short-Form Health Survey (SF-36) questionnaire.Data derived are from three cross-sectional surveys conducted in 2000, 2001 and 2002. Respondents to the postal surveys were middle-aged employees of the City of Helsinki (1799 men and 7171 women, response rate 67%).
Laaksonen, M., Rahkonne, O., Martikainen, P., Karvonen, S., Lahelma, E.   +4 more
openaire   +2 more sources

SF-36 Health Survey Update

Spine, 2000
The SF-36 (Medical Outcomes Trust, Boston, MA) is a multipurpose, short-form health survey with only 36 questions. It yields an eight-scale profile of scores as well as physical and mental health summary measures.
openaire   +4 more sources

SF-36 Health Survey

2011
Consisting of 36 items, the SF-36 is a brief survey designed to assess functional health and well-being in a variety of age, disease, and control populations [1]. Each question relates to one of eight domains: physical functioning, role-physical, bodily pain, general health perceptions, vitality, social functioning, role-emotional, and mental health ...
Azmeh Shahid, Kate Wilkinson, Shai Marcu, Colin M. Shapiro   +3 more
openaire   +1 more source