Results 121 to 130 of about 216,446 (286)

Sample sizes for the SF-6D preference based measure of health from the SF-36: a practical guide [PDF]

Background Health Related Quality of Life (HRQoL) measures are becoming more frequently used in clinical trials and health services research, both as primary and secondary endpoints.
Brazier, JE, Walters, SJ
core   +1 more source

Patient-reported utilities in advanced or metastatic melanoma, including analysis of utilities by time to death [PDF]

, 2014
Background: Health-related quality of life is often collected in clinical studies, and forms a cornerstone of economic evaluation. This study had two objectives, firstly to report and compare pre- and post-progression health state utilities in advanced
A Briggs, A Lloyd, A Montazeri, Anthony J Hatswell, AS Pickard, Becky Pennington, CC Gotay, CM McDonough, D Hogg, D Rowen, D Rowen, Dawn Lee, Donna Rowen, F Salaffi, FS Hodi, J Brazier, J Brazier, J SØrensen, J-J Grob, JD Wolchok, KM Beusterien, Louisa Pericleous, M Parker, Maximilian Lebmeier, RL Askew, S Dixon, SA Kharroubi, T WislØff   +27 more
core   +3 more sources

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

Health-related quality of life of Southern Chinese with chronic hepatitis B infection

Health and Quality of Life Outcomes, 2009
Background Few studies have evaluated the health-related quality of life (HRQOL) of Southern Chinese with chronic hepatitis B (CHB) infection. Aim To evaluate the HRQOL of Chinese patients at different stages of CHB infection and to find out factors ...
Lam Elegance TP, Lam Cindy LK, Lai CL, Yuen MF, Fong Daniel YT, So Thomas MK   +5 more
doaj   +1 more source

Single‐Cell RNA Sequencing of Human Lung Tissues Reveals Metallothionein‐Positive T Cells as a Novel Potential Marker of Susceptibility to Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing of lung samples and flow cytometry of peripheral blood, we identified a novel T cell subset with high metallothionein (MT) expression. These MT‐high T cells suppress CD8+ T cell cytotoxicity and are progressively depleted from healthy controls to chronic obstructive pulmonary disease (COPD) patients, positioning them as
Zengqing Liu, Xiaoxia Ren, Mi Mu, Huanyu Long, Jialu Lv, Zhihong Feng, Jie Liu, Jiajia Wang, Hui Deng, Fanyu Shi, Muzhi Zhang, Ruoyang Zhang, Yang Liu, Mengyu Xu, Yang Fan, Zengtao Wang, Zhe Lv, Yan Chen, Chris J. Corrigan, Ying Sun, Yahong Chen, Chen Chen, Ye Cui, Wei Wang   +23 more
wiley   +1 more source

A systematic review, psychometric analysis and qualitative assessment of generic preference-based measures of health in mental health populations and the estimation of mapping functions from widely used specific measures

Health Technology Assessment, 2014
Background: Generic preference-based measures of health like the EQ-5D and SF-6D® are increasingly being used in economic evaluation and outcome assessment.
John Brazier, Janice Connell, Diana Papaioannou, Clara Mukuria, Brendan Mulhern, Tessa Peasgood, Myfawnwy Lloyd Jones, Suzy Paisley, Alicia O’Cathain, Michael Barkham, Martin Knapp, Sarah Byford, Simon Gilbody, Glenys Parry   +13 more
doaj   +1 more source

Qualidade de vida em doentes com asma

Revista Portuguesa de Pneumologia, 2010
Resumo: Neste artigo é descrito um estudo, cujo objectivo é a medição da qualidade de vida relacionada com a saúde (QdVRS) de doentes com asma e a apresentação de uma primeira aproximação aos valores normativos, com base no SF-6D, para aquele ...
Lara Noronha Ferreira, Ulisses Brito, Pedro Lopes Ferreira   +2 more
doaj   +1 more source

A medição de preferências em saúde na população portuguesa [PDF]

, 1982
Introdução: um tema estudado pelos investigadores da economia da saúde é a medição da qualidade de vida relacionada com a saúde, em especial captando as preferências dos indivíduos em relação a determinados resultados em saúde.
Ferreira, Pedro Lopes, Ferreira, Lara de Noronha e   +1 more
core   +1 more source

Cost-effectiveness of physical fitness training for stroke survivors [PDF]

, 2018
Background Physical fitness is impaired after stroke, yet fitness training after stroke reduces disability. Several international guidelines recommend that fitness training be incorporated as part of stroke rehabilitation. However, information about cost-
Clifton, E., Collins, M., Mead, G.E., van Wijck, F.   +3 more
core   +3 more sources

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source