Results 121 to 130 of about 20,487 (260)

Failure characteristics and the energy criterion of rock with a through‐going joint under true‐triaxial unloading conditions: Insights from the DEM model

Deep Underground Science and Engineering, EarlyView.
The rock failure mode is significantly influenced by the contributing factors, such as the joint inclination, the initial confining pressure, and the unloading point. We found six typical rock failure modes after a large number of numerical tests. Abstract Excavation unloading damages rock masses, with preferential failure along geological defects in ...
Fei Liu, Changhui Liang, Sijia Liu, Yongjun Zhang, Luo Wang   +4 more
wiley   +1 more source

Consumer preferences for scanning modality to diagnose focal liver lesions [PDF]

, 2015
Objectives: Differences in the process of using liver imaging technologies might be important to patients. This study aimed to investigate preferences for scanning modalities used in diagnosing focal liver lesions.
Adam B Smith, Albrecht, Alexandra Filby, Jenkinson, Jennifer Whitty, Louise M Carr, Sirli, Smith   +7 more
core   +2 more sources

Flame‐Retardant Bio‐Based Thermo‐Flexible Phase‐Change Composites with Antivibration and Low‐Contact Resistance for Advanced Battery Thermal Management

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Flame‐retardant bio‐based thermo‐flexible phase‐change composites for advanced battery thermal management. Batteries face critical challenges in thermal management, including overheating risks, poor interfacial contact, and mechanical vibration–induced performance attenuation.
Shichao Feng, Shuofan Yue, Jiapeng Wei, Dong Zhang, Yajie Gui, Ruijuan Wang, Dongying Hu, Fangchao Cheng   +7 more
wiley   +1 more source

MCDA-based deliberation to value health states: lessons learned from a pilot study

Health and Quality of Life Outcomes, 2019
Background Health economists have shown a growing interest in deliberation and multi-criteria decision analysis (MCDA) as possible pathways to transparently integrate value judgments in cost-utility analyses.
Fabia Gansen, Julian Klinger, Wolf Rogowski   +2 more
doaj   +1 more source

A systematic review of the validity and responsiveness of EQ-5D and SF-6D for depression and anxiety [PDF]

Background: Generic preference based measures (PBM) such as the SF-6D and EQ-5D are increasingly used to inform health care resource allocation decisions.
Brazier, J., Papaioannou, D., Peasgood, T.   +2 more
core  

Mutation type‐specific transcriptomic signatures and readthrough therapy rescue in SMC1A‐related developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to investigate the molecular consequences of pathogenic variants in the SMC1A gene—particularly those associated with developmental and epileptic encephalopathy (DEE85)—and to evaluate the therapeutic potential of ataluren in restoring SMC1A function and mitigating disease‐related transcriptomic and genomic ...
Maddalena Di Nardo, Francesca Sardina, Maria M. Pallotta, Iñigo Marcos‐Alcalde, Paulino Gómez‐Puertas, Cinzia Rinaldo, Ian D. Krantz, Antonio Musio   +7 more
wiley   +1 more source

Dual Ferro‐/Piezo‐Electric Coupling in Two‐Dimensional [Bi2O2]‐Based Layered Structures for Synergistic Harvesting of Mechanical and Solar Energy

Exploration, EarlyView.
Inter‐plane 2D/2D nanosheet heterojunction based on two piezoelectric [Bi2O2]‐based layered compounds is constructed. Significantly increased piezoelectric properties of BiOBr@Bi5Ti3FeO15 by morphological regulation and interface chemical bonds. Dual‐piezoelectric field can modulate interfacial electric field and the interfacial band bending to ...
Daotong You, Xingwang Long, Zhiyong Yang, Lei Liu, Jianbang Chen, Tuan Guo   +5 more
wiley   +1 more source

AKT, ATR, and Notch Inhibitors Radiosensitize a Preclinical Model of Adenoid Cystic Carcinoma

Head &Neck, EarlyView.
ABSTRACT Background Adenoid Cystic Carcinoma (ACC) is a rare and lethal type of head and neck cancer. Standard therapy involves surgery followed by radiation therapy. The majority of ACC has MYB overexpression and MYB‐NFIB gene fusions, while Notch mutations are associated with aggressive behavior.
Shivani Thoidingjam, Sushmitha Sriramulu, Asya Haider Muratoglu, Stephen Brown, Oudai Hassan, Benjamin Movsas, Haythem Ali, Steven Chang, Patrick Ha, Farzan Siddiqui, Shyam Nyati   +10 more
wiley   +1 more source

PRM92 Exploratory Mapping of the LupusQol to the SF-6D [PDF]

Value in Health, 2012
Meacock, R., Harrison, M., Mcelhone, K., Isenberg, D., Ferenkeh-Koroma, A., Ahmad, Y., Bruce, I.N., Shelmerdine, J., Gordon, C., Griffiths, B., Maddison, P., Akil, M., Abbott, J., Teh, L.S.   +13 more
openaire   +1 more source

Microbial keystone taxa and metabolic signatures in centenarians regulate intestinal homeostasis during aging

iMeta, EarlyView.
Clostridium scindens and its metabolite indole‐3‐acetic acid (IAA) are identified as a keystone taxon and metabolic signature in centenarians. Clostridium scindens enhances microbial network stability and produces IAA via its own amidase (AMIE) and aldehyde dehydrogenase (ALDH), thus promoting intestinal homeostasis by activating the aryl hydrocarbon ...
Wei‐Chuan Lin, Cui Zhang, He‐Hua Lei, Zheng Cao, Xin Gao, Wen‐Kai Yu, Xin‐Zhi Li, Qing‐Wei Xiang, Zhi‐Wen Zhang, Shi‐Fu Pang, Wei‐Fei Luo, Deng‐Hui Xie, Li‐Min Zhang, Gang Chen   +13 more
wiley   +1 more source