Results 201 to 210 of about 19,190 (266)
Isogenic MDS-RS Patient-Derived iPSCs Define the Mis-Spliced Transcript Repertoire and Chromatin Landscape of SF3B1-Mutant Hematopoietic Stem/Progenitor Cells
, 2021 George Asimomitis, André G. Deslauriers, Andriana G. Kotini, Elsa Bernard, Davide Esposito, Malgorzata Olszewska, Nikolaos Spyrou, Juan Arango Ossa, Teresa Mortera‐Blanco, Richard P. Koche, Stuart A. Aaronson, Eva Hellström‐Lindberg, Elli Papaemmanuil, Eirini P. Papapetrou +13 moreopenalex +1 more sourceMutational Hotspot of TET2, IDH1, IDH2, SRSF2, SF3B1, KRAS, and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast Cell Tumors
, 2015 Eleonora Zorzan, Katia Hanssens, Mery Giantin, Mauro Dacasto, Patrice Dubreuil +4 moreopenalex +2 more sourcesAberrant spliceosome activity via elevated intron retention and upregulation and phosphorylation of SF3B1 in chronic lymphocytic leukemia
Molecular Therapy: Nucleic AcidsSplicing factor 3b subunit 1 (SF3B1) is the largest subunit and core component of the spliceosome. Inhibition of SF3B1 was associated with an increase in broad intron retention (IR) on most transcripts, suggesting that IR can be used as a marker of ...Manoj Kumar Kashyap, Hiren Karathia, Deepak Kumar, Roberto Vera Alvarez, Jose Vicente Forero-Forero, Eider Moreno, Juliana Velez Lujan, Carlos Ivan Amaya-Chanaga, Newton Medeiros Vidal, Zhe Yu, Emanuela M. Ghia, Paula A. Lengerke-Diaz, Daniel Achinko, Michael Y. Choi, Laura Z. Rassenti, Leonardo Mariño-Ramírez, Stephen M. Mount, Sridhar Hannenhalli, Thomas J. Kipps, Januario E. Castro +19 moredoaj Additional file 5: Table S4. of SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS
, 2018 Yumin Huang, John Hale, Yaomei Wang, Wei Li, Shijie Zhang, Jieying Zhang, Huizhi Zhao, Xinhua Guo, Jing Liu, Hongxia Yan, Karina Yazdanbakhsh, Gang Huang, Christopher D. Hillyer, Narla Mohandas, Lixiang Chen, Ling Sun, Xiuli An +16 moreopenalex +2 more sourcesHigh-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation. [PDF]
Nucleic Acids ResLuteijn MJ, Bhaskar V, Trojer D, Schürz M, Mahboubi H, Handl C, Pizzato N, Pfeifer M, Dafinca R, Voshol H, Giorgetti E, Manneville C, Garnier IPM, Müller M, Zeng F, Buntin K, Markwalder R, Schröder H, Weiler J, Khar D, Schuhmann T, Groot-Kormelink PJ, Keller CG, Farmer P, MacKay A, Beibel M, Roma G, D'Ario G, Merkl C, Schebesta M, Hild M, Elwood F, Vahsen BF, Ripin N, Clery A, Allain F, Labow M, Gabriel D, Chao JA, Talbot K, Nash M, Hunziker J, Meisner-Kober NC. +42 moreeuropepmc +1 more sourcePrognostic impact of somatic mutations and additional chromosomal abnormalities in patients with myelodysplastic syndromes and chromosome 20q deletion. [PDF]
Clin Exp MedHuang X, Li X, Liu Q, Guo J, Chen J, Zhou L, Song L, Zhang Z, Su J, Zhang Y, Yan M, He Q, Wu D, Xu F, Chang C, Wu L. +15 moreeuropepmc +1 more sourceSF3B1 mutation predicts unfavorable treatment-free survival in Chinese chronic lymphocytic leukemia patients
, 2019 Yi Miao, Yixin Zou, Danling Gu, Hongcheng Zhu, Huayuan Zhu, Li Wang, Jin‐Hua Liang, Yi Xia, Jia‐Zhu Wu, Chunlin Shao, Lei Fan, Zhen Zhang, Wei Xu, Jianyong Li +13 moreopenalex +1 more source
