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Pervasive splicing in a plant DNA virus

Pott DM, Gao M, Shi C, Wang L, Medina-Puche L, Yagci Z, Acatay SA, Zhang J, Gonzalo L, Merchante C, Gu L, Lozano-Durán R.   +11 more
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Significance of SF3B1 Mutations in Myeloid Neoplasms

Clinics in Laboratory Medicine, 2023
Myelodysplastic neoplasm with low blasts and SF3B1 mutation (MDS-LB-SF3B1) has undergone significant classification changes in the past year with the publication of the 5th edition of the World Health Organization Classification of Tumors of Haematopoietic and Lymphoid Tissues and the International Consensus Classification.
David C, Gajzer, Cecilia C S, Yeung
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SF3B1in Chronic Lymphocytic Leukemia

New England Journal of Medicine, 2012
To the Editor: Wang et al. (Dec. 29 issue)1 report that SF3B1 mutation is associated with a shorter time to initiation of treatment in patients with chronic lymphocytic leukemia. However, this result should be interpreted with caution. In the discovery cohort of 91 patients, 29 were classified as having stage 0 disease, 43 as having stage I, and 19 as ...
Jinichi, Mori, Yukie, Takahashi, Tetsuya, Tanimoto   +2 more
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Chronic Lymphocytic Leukemia withSF3B1Mutation

New England Journal of Medicine, 2012
The authors found that chronic lymphocytic leukemia in patients with mutations in the SF3B1 RNA splicing gene has a more aggressive natural history than that in patients without such mutations.
Victor, Quesada, Andrew J, Ramsay, Carlos, Lopez-Otin   +2 more
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Role Of Sf3b1 On Hematopoiesis

Blood, 2013
Abstract Frequent pathway mutation involving multiple components of the RNA splicing machinery is a cardinal feature of myeloid neoplasms showing myeloid dysplasia, in which the major mutational targets include U2AF35, ZRSR2, SRSF2 and SF3B1.
Manabu Matsunawa, Ryo Yamamoto, Masashi Sanada, Aiko Sato, Yusuke Shiozawa, Kenichi Yoshida, Yasunobu Nagata, Ayana Kon, Tetsuichi Yoshizato, Makoto Otsu, Kyoichi Isono, Haruhiko Koseki, Hiromitsu Nakauchi, Seishi Ogawa   +13 more
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Cancer-associated SF3B1 mutations inhibit mRNA nuclear export by disrupting SF3B1–THOC5 interactions

The Journal of Biochemistry
Abstract Mutations in SF3B1 are common in many types of cancer, promoting cancer progression through aberrant RNA splicing. Recently, mRNA nuclear export has been reported to be defective in cells with the SF3B1 K700E mutation. However, the mechanism remains unclear.
Gang Liu, Bo Zhao, Yueru Shi, Youzhong Wan   +3 more
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2017
SF3B1 is a highly conserved protein found in both the major and minor spliceosomes. It is part of the SF3b complex that, along with SF3a and the 12S snRNP, forms the functional 17S U2 snRNP. SF3B1 plays an important role in the recruitment, as well as the stabilization of the U2 snRNP at the branch site.
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