Results 121 to 130 of about 54,917 (299)

Investigating Cardiovascular Benefits of SGLT2 Inhibitors

, 2022
Sodium-glucose cotransporter 2 (SGLT2) inhibitors target the proximal tubule where the SGLT2 receptor is located. By blocking the receptor, glucose is forced out of the body through the urine and can no longer reabsorb into the body.
Ostroff, Jared
core   +1 more source

Short‐term clinical responses in horses and ponies treated with canagliflozin: A clinical field study

Equine Veterinary Journal, EarlyView.
Abstract Background Treatment with the sodium‐glucose co‐transporter 2 (SGLT2) inhibitor canagliflozin in insulin dysregulated (ID) horses has shown promising results in randomised clinical trials. Larger field studies are needed to further evaluate treatment responses and potential adverse effects under real‐world conditions.
Moa Hällbom, Sanna Truelsen Lindåse, Monika Wartel, Johan Bröjer   +3 more
wiley   +1 more source

Metabolic Communication by SGLT2 Inhibition

Circulation
BACKGROUND: SGLT2 (sodium-glucose cotransporter 2) inhibitors (SGLT2i) can protect the kidneys and heart, but the underlying mechanism remains poorly understood. METHODS: To gain insights on primary effects of SGLT2i that are not ...
Anja M. Billing, Young Chul Kim, Søren Gullaksen, Benedikt Schrage, Janice Raabe, Arvid Hutzfeldt, Fatih Demir, Elina Kovalenko, Moritz Lassé, Aurelien Dugourd, Robin Fallegger, Birgit Klampe, Johannes Jaegers, Qing Li, Olha Kravtsova, Maria Crespo-Masip, Amelia Palermo, Robert A. Fenton, Elion Hoxha, Stefan Blankenberg, Paulus Kirchhof, Tobias B. Huber, Esben Laugesen, Tanja Zeller, Maria Chrysopoulou, Julio Saez-Rodriguez, Christina Magnussen, Thomas Eschenhagen, Alexander Staruschenko, Gary Siuzdak, Per L. Poulsen, Clarissa Schwab, Friederike Cuello, Volker Vallon, Markus M. Rinschen   +34 more
openaire   +3 more sources

Chronic High‐Salt Intake Reprograms Metabolic Homeostasis Driven by Dietary Rice Varieties via Microbial and Metabolite Associations

iMetaMed, EarlyView.
Using a 2% salt diet and a 10‐month feeding to model chronic human sodium exposure, we found that black rice improved glucose tolerance and short‐chain fatty acids, but 2% salt inverted black rice's blood glucose benefits. White rice + 2% salt treatment uniquely increased short‐chain fatty acids.
Xiaofang Li, Fangyang Chen, Ping Chen, Yage Wang, Mengke Yuan, Zhuojun Li, Hao Chen, Zongkang Zhang, Kaikai Li   +8 more
wiley   +1 more source

Research Progress of Berberine in Kidney Disease: Targeting Mitochondria and Ferroptosis

iNew Medicine, EarlyView.
This figure illustrates the model‐specific renoprotective mechanisms of berberine (BBR) across three major kidney diseases. From left to right, the diagram shows that BBR targets distinct core pathways depending on the pathological context: in diabetic nephropathy (DN), BBR activates AMPK to improve mitochondrial energy metabolism; in acute kidney ...
Liuqing Wang, Rongyu Guo, Xiaojun Feng, Liqin Tang   +3 more
wiley   +1 more source

Geriatric Regenerative Medicine: Mechanisms, Strategies, and Clinical Translation

iNew Medicine, EarlyView.
The pathological drivers of aging—stem cell exhaustion, cellular senescence with SASP, and aged extracellular matrix—are precisely targeted by three corresponding mechanism‐based strategies: stem cell therapies (rejuvenation, regeneration, and replacement), senolytic/senomorphic agents (D + Q, fisetin, vaccines, and CAR‐T), and senescence‐targeting ...
Qiang Li, Chaoyang Wang, Junci Chong, Zishu Liu, Boying Wang, Shiyu Liu, Xingcai Zhang, Hengrui Liu, Shuanglin Qin, ChuTse Wu, Beidong Chen, Zhigang Chang   +11 more
wiley   +1 more source

SGLT2-is in Acute Heart Failure

Journal of Clinical Medicine
Despite the wealth of evidence in favour of SGLT2 inhibitor use in patients with chronic heart failure, their role in the very early stages of heart failure is still unclear. While the latest update of the European Society of Cardiology guidelines on heart failure advocates the use SGLT2 inhibitors in the acute phases of heart failure based on the ...
Matteo Bianco, Concetta Di Nora, Renata De Maria, Amir Hassan Mousavi, Samuela Carigi, Luisa De Gennaro, Paolo Manca, Maria Vittoria Matassini, Vittoria Rizzello, Maria Denitza Tinti, Giovanna Geraci, Attilio Iacovoni, Furio Colivicchi, Massimo Grimaldi, Fabrizio Oliva   +14 more
openaire   +2 more sources

Impact of Dapagliflozin on MRI‐Derived Epicardial Adipose Tissue: Secondary Imaging Analysis of a Randomized Trial

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Epicardial adipose tissue (EAT) is a metabolically active fat depot associated with cardiovascular risk and represents a modifiable imaging biomarker. Studies have shown that sodium–glucose cotransporter‐2 (SGLT2) inhibitors reduce EAT thickness in patients with type 2 diabetes mellitus (T2DM). However, it is unclear whether this is
Min Jae Cha, Negar Firoozeh, Anna V. Naumova, Peter Muzi, Karen G. Ordovas, Dennis D. Wang, Daniel Isquith, Chuck Maynard, Xue‐Qiao Zhao, Francis Kim   +9 more
wiley   +1 more source

Practical Considerations and Implementation of Sodium-Glucose Co-Transporter-2 Inhibitors in Chronic Kidney Disease: Who, When, and How? A Position Statement by Nephrologists

Journal of Primary Care & Community Health
Introduction: There remains an unmet need to reduce kidney and cardiovascular risk in patients with chronic kidney disease (CKD). This report is therefore intended to provide real-world clinical guidance to primary care providers on sodium-glucose co ...
Anjay Rastogi, Ashté Collins, Ellie Kelepouris, Wayne Kotzker, John P. Middleton, Minesh Rajpal, Prabir Roy-Chaudhury, Glenn M. Chertow   +7 more
doaj   +1 more source

Is GFR decline induced by SGLT2 inhibitor of clinical importance? [PDF]

Background Use of sodium-glucose-cotransporter-2 (SGLT2) inhibitors often causes an initial decline in glomerular filtration rate (GFR). This study addresses the question whether the initial decline of renal function with SGLT2 inhibitor treatment is ...
Bosch, Agnes, Schiffer, Mario, Bramlage, Peter, Schmieder, Roland E., Kannenkeril, Dennis, Günes-Altan, Merve, Striepe, Kristina   +6 more
core   +1 more source