Results 131 to 140 of about 25,234 (166)

Discovery of non-glucoside SGLT2 inhibitors

Bioorganic & Medicinal Chemistry Letters, 2011
A series of benzothiazinone and benzooxazinone derivatives were discovered as SGLT2 inhibitors. The optimization led to the discovery of compounds 31 and 32, which exhibited similar potency and better SGLT1 selectivity compared to dapagliflozin. These compounds may provide novel promising scaffolds, which are different from phlorizin-based SGLT2 ...
An-Rong, Li, Jian, Zhang, Joanne, Greenberg, TaeWeon, Lee, Jiwen, Liu   +4 more
openaire   +2 more sources

SGLT2 inhibitors may prevent diabetes

Nature Reviews Nephrology, 2022
Daniel V. O’Hara, Meg J. Jardine
openaire   +2 more sources

Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment

Cell, 2023
Marlies Meisel
exaly  

Trends in kinase drug discovery: targets, indications and inhibitor design

Nature Reviews Drug Discovery, 2021
Misty M Attwood, Stefan Knapp
exaly  

SGLT2 inhibitors

Clinical Therapeutics, 2015
openaire   +1 more source

SGLT2 inhibitors

British Journal of Cardiology, 2017
openaire   +1 more source

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Cell, 2020
Markus Hoffmann, Nadine Krüger, Tobias S Schiergens   +2 more
exaly  

A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia

Cancer Cell, 2019
Andrei V Krivtsov, Jayant Y Gadrey, Charlie Hatton   +2 more
exaly  

SGLT2 inhibitors in clinical practice

The Lancet Diabetes & Endocrinology
Lars, Rydén, Anna, Norhammar
openaire   +2 more sources

SGLT2-Inhibitor bei Herzinsuffizienz

CME, 2022
openaire   +1 more source