Results 51 to 60 of about 662,207 (147)

Combination SGLT2 Inhibitor and Glucagon Receptor Antagonist Therapy in Type 1 Diabetes: A Randomized Clinical Trial [PDF]

OBJECTIVE: To examine the effects of insulin-adjunctive therapy with a sodium-glucose cotransporter 2 (SGLT2) inhibitor and a glucagon receptor antagonist (GRA) on glycemia, insulin use, and ketogenesis during insulinopenia in type 1 diabetes.
Le Roux, Melissa J, Boeder, Schafer C, Thomas, Robert L, Gregory, Justin M, Giovannetti, Erin R, Pettus, Jeremy H   +5 more
core   +1 more source

Severe intoxication caused by sodium-glucose cotransporter 2 inhibitor overdose: a case report

BMC Pharmacology and Toxicology, 2020
Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors inhibit SGLT2, which is expressed in the proximal renal tubule, and thus reduce blood glucose levels by enabling the urinary excretion of excess glucose.
Miho Nakamura, Junya Nakade, Tadashi Toyama, Masaki Okajima, Takumi Taniguchi   +4 more
doaj   +1 more source

Sodium-glucose cotransporter 2 inhibitors and the risk of kidney cancer among patients with type 2 diabetes: a population-based cohort study

BMC Medicine
Background There is an important need to develop clinical strategies to reduce the risk of incident kidney cancer, especially in patients with type 2 diabetes (T2D) often accompanied by chronic kidney disease. Here, we investigated whether sodium-glucose
Minyoung Lee, Hokyou Lee, Eun-Jin Kim, Dasom Son, Hyeok-Hee Lee, Hyeon Chang Kim, Eun Seok Kang   +6 more
doaj   +1 more source

Combination Therapy with an SGLT2 Inhibitor as Initial Treatment for Type 2 Diabetes: A Systematic Review and Meta-Analysis

, 2019
Background: Guidelines differ with regard to indications for initial combination pharmacotherapy for type 2 diabetes. Aims: To compare the efficacy and safety of (i) sodium-glucose cotransporter 2 (SGLT2) inhibitor combination therapy in treatment-na ...
Richard O. Day, Tamara Y. Milder, Jerry R. Greenfield, Sophie L. Stocker, Dorit Samocha-Bonet, Christina Abdel Shaheed, Lucy McGrath-Cadell   +6 more
core   +1 more source

PERANAN SGLT2 INHIBITOR PADA HEART FAILURE [PDF]

Heart failure adalah suatu sindrom kompleks yang terjadi akibat gangguan jantung yang merusak kemampuan ventrikel untuk mengisi dan memompa darah secara efektif serta merupakan penyebab utama kematian atau sangat berperan pada kematian. Sodium-glucose Co-
Sulfianti, Sri, Maricar, Fadillah, Wisudawan, Wisudawan, Nurhikmawati, Nurhikmawati, Rumlawan, Sarinah Mandella   +4 more
core   +1 more source

Effects of sodium glucose co-transporter-2 inhibitors by diabetes status and level of albuminuria: a collaborative meta-analysis [PDF]

Importance: There is uncertainty about the effects of SGLT2 inhibitors (SGLT2i) in certain types of patients with chronic kidney disease (CKD), with international guidelines offering different strengths of recommendation based on diabetes status and ...
Neuen, BL, Wanner, C, Haynes, Richard, Herrington, William, Roddick, Alistair, Staplin, natalie   +5 more
core   +1 more source

Association between SGLT2 inhibitors and recurrence of cerebrovascular events in patients with type 2 diabetes: A population-based cohort study

Diabetes & Vascular Disease Research
Objective Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been studied for their effects on cardiovascular disease, cognitive impairment, dementia, Parkinson’s disease, and cerebrovascular disease, with evidence suggesting a reduced risk of ...
Mee Hyeon Kim, Jin Yeon Gil, Kyung Hyun Min, Jun Hyeob Kim, Jun Hyuk Park, Sunny Park, Ji Min Han, Kyung Eun Lee   +7 more
doaj   +1 more source

Trends in Healthcare Costs in Heart Failure and Its Clinical Phenotypes During the Implementation of SGLT2 Inhibitors: A Finnish Registry Study

ClinicoEconomics and Outcomes Research
Johan Liseth Hansen,1,2 Miikka Tarkia,3 Marija Vasilevska,1 Patrik Sandin,1 Eralda Asllanaj,4 Karlijn Wammes,4 Johan Mesterton,1,5 KE Juhani Airaksinen6 1Quantify Research, Stockholm, Sweden; 2Department of Health Management and Health Economics ...
Hansen JL, Tarkia M, Vasilevska M, Sandin P, Asllanaj E, Wammes K, Mesterton J, Airaksinen KEJ   +7 more
doaj  

Unmasking of normocalcemic primary hyperparathyroidism after sodium-glucose cotransporter-2 inhibitor initiation

European Journal of Case Reports in Internal Medicine
Sodium-glucose cotransporter-2 (SGLT2) inhibitors have complex interactions with bone metabolism, including an increase in parathyroid hormone (PTH) levels.
Christodoulos Dolapsakis, Emmanouil Karofylakis, Stamatios Chalvatzis   +2 more
doaj   +1 more source

Effect of Sodium-Glucose Cotransporter-2 Inhibitors (SGLT2is) on Atrial Fibrillation Recurrence Rate in Patients with Type 2 Diabetes Mellitus: A Mid-Term Follow-up [PDF]

Zagazig University Medical Journal
Background: Atrial Fibrillation (AF) deteriorates the prognosis of Diabetes mellitus (DM), and DM is a significant risk factor for the occurrence of AF.
Shaimaa Wageeh, Ahmed Marie, Abdelrahman Adel, Waleed Elawady, Ashraf Dewedar   +4 more
doaj   +1 more source