Results 41 to 50 of about 29,252 (251)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Shade and Cd Conditions Strongly Impact the Physiological Responses of Purple Perilla

Frontiers in Environmental Science, 2022
Plant metabolic regulation is an important strategy for dealing with abiotic stress, which can initiate dramatic changes in metabolite profiles. Metabolomic studies have been extensively used to reveal the responses of plants to abiotic stress, but ...
Yiran Zhang, Yiran Zhang, Yiran Zhang, Hanzhi Zhang, Hanzhi Zhang   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Development of a novel dental shade determination application [PDF]

Journal of Dental Research, Dental Clinics, Dental Prospects, 2020
Determining the shade of dental materials is a challenging requirement for the restorative dentist. Improper shade selection is the second cause for laboratory remakes, resulting in inefficiency and additional cost, and unnecessary stress for the ...
Les Kalman
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Shade tolerance in wheat is related to photosynthetic limitation and morphological and physiological acclimations

Frontiers in Plant Science
Low solar irradiance reaching the canopy due to fog and heavy haze is a significant yield-limiting factor worldwide. However, how plants adapt to shade stress and the mechanisms underlying the reduction in leaf photosynthetic capacity and grain yield ...
Yong Li, Jiarong Zhao, Hongliang Ma, Lixia Pu, Jiarui Zhang, Xiulan Huang, Hongkun Yang, Hongkun Yang, Hongkun Yang, Gaoqiong Fan, Gaoqiong Fan, Gaoqiong Fan   +11 more
doaj   +1 more source

Effects of shade stress on morphophysiology and rhizosphere soil bacterial communities of two contrasting shade-tolerant turfgrasses [PDF]

, 2019
Abstract Background: Perturbations in the abiotic stress directly or indirectly affect plants and root-associated microbial communities. Shade stress presents one of the major abiotic limitations for turfgrass growth, as light availability is severely reduced under a leaf canopy.
Juanjuan Fu, Yilan Luo, Pengyue Sun, Jinzhu Gao, Donghao Zhao, Peizhi Yang, Tianming Hu   +6 more
openaire   +2 more sources

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Growth and stoichiometry of Pinus yunnanensis seedlings in response to shade and drought interaction

Guangxi Zhiwu
In order to investigate the growth of Pinus yunnanensis seedlings and the stoichiometric characteristics of carbon(C), nitrogen(N)and phosphorus(P)of different organs in response to shade and drought treatments and the adaptive mechanism, the growth of P.
WEN Chengjing1,2,3, WU Junwen1,2,3*, JING Huiqing1,2,3, CHEN Gang1,2,3, LI Zhiqi1,2,3, DUAN Guihe1,2,3
doaj   +1 more source