Results 211 to 220 of about 805,515 (280)

Integrated Multiomic Analysis Reveals an EBV‐Associated MIF–SPP1+ Macrophage Axis Linking Tumor Stemness and Immune Dysfunction in Nasopharyngeal Carcinoma

open access: yesAdvanced Science, EarlyView.
This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu   +15 more
wiley   +1 more source

Highly Linear Perovskite Synapses for Neuromorphic Computing

open access: yesAdvanced Science, EarlyView.
Voltage spikes applied to an Au/ACI‐phase perovskite/ITO memristor emulate the ionic signaling of a biological synapse, generating a tunable postsynaptic current. The vertically aligned perovskite film confines iodide‐vacancy migration, enabling highly linear, and symmetric conductance updates with 100 states and 5.5 aJ per event. Such synapses sustain
Zhongwen Sun   +7 more
wiley   +1 more source

Deep Learning for AD Risk Screening and Progression Prediction

open access: yesAdvanced Science, EarlyView.
A pretrained MRI‐based deep learning model generalizes from Western cohorts to an independent Chinese cohort, detects Alzheimer's disease with high sensitivity, and identifies elevated AD risk years before diagnosis. Its risk scores align with cognition and plasma biomarkers, and individualized brain risk maps uncover clinically distinct subtypes ...
Bin Lu   +12 more
wiley   +1 more source

Steps Toward Vitrification and Banking of Coral Larvae Using Field‐Friendly Cryomesh Technology

open access: yesAdvanced Science, EarlyView.
Cryomesh enables a low‐tech cryopreservation method, adding a valuable option to the coral reef conservation toolkit. The approach reveals how size, toxicity, and developmental stage govern larval survival, while modeling links cooling and rewarming rates to a theoretical upper volume limit.
E. Michael Henley   +15 more
wiley   +1 more source

Rethinking Cochlear Implants: The Need for Precise Temporal Coding

open access: yesAdvanced Science, EarlyView.
Spatial hearing relies on sensitivity to interaural temporal cues, but this sensitivity is often poorly developed in patients with cochlear implants, particularly those with early‐onset hearing loss. Rats with cochlear implants, however, demonstrate excellent temporal sensitivity, suggesting that this limitation is not inevitable.
Nicole Rosskothen‐Kuhl   +1 more
wiley   +1 more source

Light-defined cold acclimation reprograms organ-specific metabolic and transcriptional landscapes for salt stress responses in maize. [PDF]

open access: yesPlant Cell Rep
Benczúr K   +11 more
europepmc   +1 more source

Mechanically‐Gated Stochastic Resonance for All‐Optical Acoustic Sensing in Noisy Environments

open access: yesAdvanced Science, EarlyView.
A mechanically‐gated stochastic resonance (MGSR) sensing system is demonstrated, wherein stochastic resonance is enabled by an all‐optical bistable fiber Bragg grating feedback loop and gated by mechanical resonance. Under ambient noise, the system generates bistable outputs satisfying the Kramers escape‐rate condition, yielding signal‐to‐noise ratio ...
Xuyu Zhang   +9 more
wiley   +1 more source

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