Results 51 to 60 of about 400,387 (277)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Effects of Graphene Oxide Nanosheets in Freshwater Biofilms

open access: yesMolecules, 2023
Graphene oxide (GO) properties make it a promising material for graphene-based applications in areas such as biomedicine, agriculture, and the environment. Thus, its production is expected to increase, reaching hundreds of tons every year.
Diana Matos   +4 more
doaj   +1 more source

Shape-from-shading using the heat equation [PDF]

open access: yes, 2006
This paper offers two new directions to shape-from-shading, namely the use of the heat equation to smooth the field of surface normals and the recovery of surface height using a low-dimensional embedding.
Hancock, Edwin R., Robles-Kelly, Antonio
core   +3 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Terrain analysis using radar shape-from-shading [PDF]

open access: yes, 2003
This paper develops a maximum a posteriori (MAP) probability estimation framework for shape-from-shading (SFS) from synthetic aperture radar (SAR) images.
Bors, A G, Hancock, E R, Wilson, R C
core   +3 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

(Effect of shading and spraying with alcoholic sugars on the physiological lifespan of Seeds celery plant) [PDF]

open access: yesمجلة جامعة كركوك للعلوم الزراعية
The experiment was carried out at the research station north Ramadi city of the College of Agriculture – University Of Anbar to study the effect of shading and spraying with sugar alcohols (sorbitol) on the physiological lifespan of celery (Apium ...
Omar Harby, Hmood G. Khaleefa
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

A graph-spectral approach to shape-from-shading [PDF]

open access: yes, 2004
In this paper, we explore how graph-spectral methods can be used to develop a new shape-from-shading algorithm. We characterize the field of surface normals using a weight matrix whose elements are computed from the sectional curvature between different ...
Hancock, E R, Robles-Kelly, A
core   +2 more sources

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