Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Accelerated Progression of Gait Impairment in Parkinson's Disease and REM Sleep Without Atonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective People with Parkinson's disease (PD) and rapid eye movement (REM) sleep without atonia (RSWA) often have more severe gait disturbances compared to PD without RSWA. The association between the presence and expression of RSWA and the rate of progression of gait impairment in PD is unknown.
Sommer L. Amundsen‐Huffmaster +11 more
wiley +1 more source
Impact of solar shading geometry on building energy use in hot humid climates with special reference to Malaysia [PDF]
, 2005 External solar shading devices can substantially reduce the cooling load of buildings and large energy savings can be achieved. Hence, intercepting the radiant heat wave before penetrating to the internal environment through envelope openings is the main
Ahmad, M. Hamdan +2 more
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez +12 more
wiley +1 more source
Diffusion Tractography Biomarker for Epilepsy Severity in Children With Drug‐Resistant Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To develop a novel deep‐learning model of clinical DWI tractography that can accurately predict the general assessment of epilepsy severity (GASE) in pediatric drug‐resistant epilepsy (DRE) and test if it can screen diverse neurocognitive impairments identified through neuropsychological assessments.
Jeong‐Won Jeong +7 more
wiley +1 more source
Structural econometric approach to bidding in the main refinancing operations of the Eurosystem [PDF]
This paper contributes to the existing literature on central bank repoauctions. It is based on a structural econometric approach, whereby the primitives of bidding behavior (individual bid schedules and bid-shading components) are directly estimated ...
Cassola, Nuno +2 more
core +3 more sources
Implementation of a new bi-directional solar modelling method for complex facades within the ESP-r building simulation program [PDF]
, 2009 This paper provides an overview of a new method for modelling the total solar energy transmittance. It is implemented in the ESP-r building simulation program to model complex façades such as double glazed façades with external, internal or integrated ...
Frontini, Francesco +4 more
core
Amyotrophic Lateral Sclerosis Prevalence Projection in 2040: A Less Rare Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To project ALS prevalence across multiple countries through 2040, accounting for both population aging and increased survival. Methods Data from the Piemonte and Valle d'Aosta ALS register (PARALS) was used to estimate the trends in incidence and prevalence from 2005 to 2019. Survival trends over this period were also assessed.
Rosario Vasta +18 more
wiley +1 more source
Modification to the shading routine in the HREC orbital drag coefficient computer program Final report [PDF]
Shading and pre-shading techniques for modified orbital drag coefficient computer ...
Chrietzberg, J. Y. +2 more
core +1 more source
Investigation of mesoscale pre-convective forcing mechanisms [PDF]
, 1984 The installation and testing of a numerical mesoscale boundary layer model is discussed. A data analysis is first made using the rawinsonde network which shows a strong baroclinic zone developing in the region where convection was initiated. The observed
Mcnider, R. T.
core +1 more source