Results 41 to 50 of about 247,919 (347)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Approximating Shading Ratio Using the Total-Sky Imaging System: An Application for Photovoltaic Systems

Energies, 2022
In recent years, a determined shading ratio of photovoltaic (PV) systems has been broadly reviewed and explained. Observing the shading ratio of PV systems allows us to navigate for PV faults and helps to recognize possible degradation mechanisms ...
Mahmoud Dhimish, Pavlos I. Lazaridis
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Enhancing Daylight and Energy Efficiency in Hot Climate Regions with a Perforated Shading System Using a Hybrid Approach Considering Different Case Studies

Buildings
Direct sunlight causes glare and reduces indoor daylight quality, making shading systems essential. This study proposes and validates a perforated shading screen (PSS) to enhance daylighting and energy efficiency. A hybrid approach integrating parametric
Basma Gaber, Changhong Zhan, Xueying Han, Mohamed Omar, Guanghao Li   +4 more
doaj   +1 more source

The Effect of Collector Azimuth on Inter-Row Shading in Photovoltaic Fields—A Comprehensive Point of View

Energies, 2023
Rooftop buildings, mountain terrains, rivers, and lake beds may be oriented at different azimuths other than due south (in the northern hemisphere), on which photovoltaic (PV) systems may be installed.
Avi Aronescu, Joseph Appelbaum
doaj   +1 more source

Towards Grower-friendly Apple Crop Thinning by Tree Shading [PDF]

, 2008
Light management with shading nets, which reduce sunlight by 74%, might be an alternative to chemicals commonly used for thinning on apple trees. To study the effect of shading on crop load and fruit quality, trials were conducted in field experiments ...
Bertschinger, L., Kockerols, K., Schwan, S., Stadler, W., Widmer, A.   +4 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Dynamic Integration of Shading and Ventilation: Novel Quantitative Insights into Building Performance Optimization

Buildings
Buildings consume nearly 40% of global energy, necessitating innovative strategies to balance energy efficiency and occupant comfort. While shading and ventilation are critical to sustainable design, they are often studied independently, leaving gaps in ...
Silvia Mazzetto
doaj   +1 more source

Design a photovoltaic system based on maximum power point tracking under partial shading [PDF]

, 2019
Photovoltaic systems have been given special attention given their long-term potential advantages. Solar panels can produce maximum power at specific operating points called maximum power points (MPP).
Ma’allin, Usama Abdullahi
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source