Results 61 to 70 of about 52,732 (293)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Downlink Analysis for a Heterogeneous Cellular Network

, 2014
In this paper, a comprehensive study of the the downlink performance in a heterogeneous cellular network (or hetnet) is conducted. A general hetnet model is considered consisting of an arbitrary number of open-access and closed-access tier of base ...
Brown, Timothy X, Liu, Madhusudhanan, Prasanna, Restrepo, Juan G., Youjian   +4 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Impact of Compression and Small Cell Deployment on NB-IoT Devices Coverage and Energy Consumption with a Realistic Simulation Model

Sensors, 2021
In the last few years, Low-Power Wide-Area Network (LPWAN) technologies have been proposed for Machine-Type Communications (MTC). In this paper, we evaluate wireless relay technologies that can improve LPWAN coverage for smart meter communication ...
Mehdi Zeinali, John S. Thompson
doaj   +1 more source

Multi-tier Network Performance Analysis using a Shotgun Cellular System

, 2011
This paper studies the carrier-to-interference ratio (CIR) and carrier-to-interference-plus-noise ratio (CINR) performance at the mobile station (MS) within a multi-tier network composed of M tiers of wireless networks, with each tier modeled as the ...
Baker, Kenneth R., Brown, Timothy X, Liu, Madhusudhanan, Prasanna, Restrepo, Juan G., Youjian   +5 more
core   +1 more source

Capacity ofκ-μShadowed Fading Channels [PDF]

International Journal of Antennas and Propagation, 2014
The ergodic capacity of fading channels modeled with aκ-μshadowed distribution is investigated to derive closed-form expressions. Theκ-μshadowed distribution is of particular interest because it contains, as special cases, other classical ones like one-side Gaussian, Rayleigh, Rician, Nakagami-m,κ-μ, and Rician shadowed distributions.
Celia García-Corrales, Francisco J. Cañete, José F. Paris   +2 more
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Inter- and Intrasite Correlations of Large-Scale Parameters from Macrocellular Measurements at 1800 MHz

EURASIP Journal on Wireless Communications and Networking, 2007
The inter- and intrasite correlation properties of shadow fading and power-weighted angle spread at both the mobile station and the base station are studied utilizing narrowband multisite MIMO measurements in the 1800 MHz band.
Jaldén Niklas, Zetterberg Per, Ottersten Björn, Garcia Laura   +3 more
doaj  

An empirical study on gamma shadow fading based localization [PDF]

2017 25th European Signal Processing Conference (EUSIPCO), 2017
En este documento, proponemos un estimador de probabilidad máxima para los sistemas de localización de interiores basados en la intensidad de la señal recibida (RSS) mediante la explotación del modelo de desvanecimiento de la sombra gamma. Con el fin de investigar la validez del método propuesto en un entorno realista, desarrollamos un banco de pruebas
Saliha Büyükçorak, Güneş Karabulut Kurt, Abbas Yongaçoğlu   +2 more
openaire   +2 more sources