Results 141 to 150 of about 705,910 (335)
Advanced Science, EarlyView.This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li +7 more
wiley +1 more source
Low cost anti-galling bushings [PDF]
, 1972 Heat shrinkable Teflon tubing is cut to size, slipped onto shaft, heated to shrink tightly to shaft, or machined to final outside diameter size. Shaft bushings fabricated from shrinkable Teflon tubing provide economic close fitting sleeves that prevent ...
Spencer, E. O.
core +1 more source
Advanced Science, EarlyView.Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao +11 more
wiley +1 more source
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source
Intermediate rotating ring improves reliability of dynamic shaft seal [PDF]
, 1966 Intermediate rotating ring improves the reliability of dynamic shaft seals whose rubbing surfaces wear down rapidly at high shaft speeds. The rotating ring is placed between the rotating shaft sealing surfaces and the stationary surface, and driven at ...
Mesny, P. R.
core +1 more source
Cytoprotection Concepts for Ischemic Stroke in the Recanalization Era
Advanced Science, EarlyView.This review provides detailed information on modern cytoprotective strategies for ischemic stroke in the context of recanalization therapies. It derives their rationale based on contemporary knowledge of stroke pathophysiology and discusses the role of advanced imaging approaches as well as concepts for novel clinical trial designs.
Johannes Boltze, Marc Fisher
wiley +1 more source
Rotating shaft seal Patent [PDF]
, 1969 Liquid-vapor interface seal design for turbine rotating shafts including helical and molecular pumps and liquid cooling of mercury ...
Bosco, G. B., Jr., Lessley, R. L.
core +1 more source
Borophene: Crucial Challenges and the Way Forward
Advanced Science, EarlyView.This review explores the challenges and progress in borophene research, focusing on synthesis strategies, structural properties, and potential applications. It highlights key experimental breakthroughs, discusses theoretical insights into borophene's unique features, and addresses pathways for overcoming stability and scalability issues.
Zhixuan Li +3 more
wiley +1 more source
Test stand system for vacuum chambers [PDF]
, 1973 A test stand system for supporting test items in a vacuum chamber is described. The system consists of a frame adapted to conform to the inside of the vacuum chamber and supporting a central vertical shaft.
Newman, D. F.
core +1 more source